Inhibitory Effect of Tetramerized Single-Chain Variable Fragment of Anti-Cyclic Citrullinated Peptide Antibodies on the Proliferation, Activation, and Secretion of Cytokines of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis In Vitro Co-Culture System

Inhibitory Effect of Tetramerized Single-Chain Variable Fragment of Anti-Cyclic Citrullinated Peptide Antibodies on the Proliferation, Activation, and Secretion of Cytokines of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis In Vitro Co-Culture System

Tetramerized single chain variable fragment (scFv) anti-cyclic citrullinated peptide (TeAb-CCP) is built tetramerized scFv anti-cyclic peptide citrullinated (CCP) antibody to p53 domain tetrameric, aimed to investigate the effect on fibroblast-like synoviocytes (FLSs) proliferation, migration, invasion, and production of inflammatory mediators in the co-culture system in vitro peripheral mononuclear cells (PBMC) and FLSs. TeAb-CCP constructed by modifying the monovalent scFv antibodies to PKC with tetrameric domain p53 to increase affinity. FLSs isolated and cultured from rheumatoid arthritis (RA) patients and control subjects.

A co-culture system peripheral mononuclear cells (PBMC) and FLSs used. FLSs proliferation, migration and invasion were measured by MTT, the initial tests, and Transwell chamber. The supernatant was measured for cytokines, chemokines, metalloproteinases, and anti-CCP antibodies by Luminex liquid phase protein chip and ELISA. TeAb-CCP FLSs significantly inhibit proliferation in a dose-dependent fashion, with maximal action at a concentration of 100 mg / ml on day 7 in a co-culture with PBMCs and FLSs, but not the same as just FLSs.

TeAb-CCP was significantly suppressed FLSs migration and invasive ability compared with controls. Significantly lower levels of interleukin (IL) -6, IL-8, RANKL, a protein arginine deiminase (PAD) -2, PAD4, metalloproteinase (MMP) -1 and MMP-3 and anti-CCP antibodies found in the supernatant co -budaya TeAb-CCP group. Instead, transforming growth factor-β (TGF-β) and tissue inhibitor of metalloproteinase-2 (TIMP-2) increased significantly in the group TeAb-CCP.

There is no significant difference of IL-1a, IL-10, IL-17, TNF, VEGF and FGF was found between the two groups. As a blocking antibody, TeAb-CCP can significantly inhibit RA PBMC to produce pro-inflammatory mediators, and furthermore, inhibit proliferation, activation, migration, and invasion in vitro FLSs. In turn, it is suggested that a modified self citrullinated epitopes may be a new target for the treatment of RA.

 Inhibitory Effect of Tetramerized Single-Chain Variable Fragment of Anti-Cyclic Citrullinated Peptide Antibodies on the Proliferation, Activation, and Secretion of Cytokines of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis In Vitro Co-Culture System
Inhibitory Effect of Tetramerized Single-Chain Variable Fragment of Anti-Cyclic Citrullinated Peptide Antibodies on the Proliferation, Activation, and Secretion of Cytokines of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis In Vitro Co-Culture System

Mst1 promote mitochondrial dysfunction and apoptosis in oxidative stress-induced rheumatoid arthritis synoviocytes

In this study, we investigated the role of macrophage stimulating 1 (mst1) SIRT1 and AMPK-signaling pathway in oxidative stress-induced mitochondrial dysfunction and apoptosis seen in rheumatoid arthritis associated fibroblast-like synoviocytes (RA-FLSs). Mst1 mRNA and protein expression was significantly higher in hydrogen peroxide (H2O2) -treated RA-FLSs of untreated control. H2O2 treatment induced mitochondrial apoptotic pathway by activating caspase3 / 9 and Bax in RA-FLSs.

In addition, H2O2 treatment significantly reduced the mitochondrial membrane potential and mitochondrial state 3 and state 4 respiration, but increased reactive oxygen species (ROS). Mst1 silencing significantly reduce oxidative stress induced mitochondrial dysfunction and apoptosis in RA-FLSs. SIRT1 expression was reduced significantly in H2O2-treated RA-FLSs, but higher in H2O2-treated mst1-RA-FLSs silenced.

Pretreatment with selisistat (SIRT1-specific inhibitor) or compound C (AMPK antagonist) significantly reduces the survival and function of mitochondria in H2O2-treated mst1-RA-FLSs silenced by inhibiting the function or expression of SIRT1 SIRT1, respectively.

Human Fibroblast-Like Synoviocyte Normal Tissue, Adult

ABC-TC3619 1 vial Ask for price
Description: Human Fibroblast-Like Synoviocytes (HFLS) are isolated from normal synovial tissues. They are cryopreserved at second passage and can be cultured and propagated at least 5 population doublings.

Human Fibroblast-Like Synoviocyte Osteo Arthritis, Adult

ABC-TC3620 1 vial Ask for price
Description: Human Fibroblast-Like Synoviocytes (HFLS) are isolated from synovial tissues obtained from patients with Rheumatoid Arthritis (RA) / Osteoarthritis (OA). They are cryopreserved at second passage and can be cultured and propagated at least 5 population doubling.

Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult

ABC-TC3621 1 vial Ask for price
Description: Human Fibroblast-Like Synoviocytes (HFLS) are isolated from synovial tissues obtained from patients with Rheumatoid Arthritis (RA) / Osteoarthritis (OA). They are cryopreserved at second passage and can be cultured and propagated at least 5 population doubling.

Human Synoviocytes

ABC-TC3829 1 vial Ask for price
Description: Human synoviocytes (HS), the predominant cell type of healthy synovial tissue, are fibroblast-like cells. The Synoviocytes form a distinct structure called the synovial lining layer. Electron microscopy revealed extensive cell-to-cell contacts within the lining layer. The Synoviocytes produce synovial fluid components and are responsible for absorption from the joint cavity, and for blood/synovial fluid exchanges. The synoviocytes proliferate, show anchorage-independent growth, and also secrete a variety of effector molecules that promote inflammation and joint destruction and, themselves are part of a complex network of autocrine and paracrine acting factors. The synoviocytes express cadherin-11 providing new insight into synovial tissue organization and morphogenesis and of interest as a therapeutic target.HS from Gentaur Research Laboratories are isolated from human synovium. HS are cryopreserved at passage one cultures and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HS are characterized by their fibroblast-like morphology, growth pattern and immunocytochemistry of CD 90 and fibronectin. HS are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HS are guaranteed for 15 population doublings at the conditions provided by Gentaur Research Laboratories.

Synoviocytes Growth Medium

cAP-68 500ml
EUR 148.5

Human Cryopreserved Synoviocytes, OA

CDD-H-2910-OA 1 vial
EUR 575

Human Cryopreserved Synoviocytes, RA

CDD-H-2910-RA 1 vial
EUR 575

Immortalized Human Synoviocytes-SV40

CSC-I2279Z One Frozen vial Ask for price

Human Cryopreserved Synoviocytes, Normal

CDD-H-2910-N 1 vial
EUR 575

Human Primary Osteoarthritis Synovial Fibroblasts

T5408 5 x 10^5/ 1.0 ml Ask for price

Human Primary Rheumatoid Arthritis Synovial Fibroblasts

T5409 5 x 10^5 / 1.0 ml
EUR 1595

Primary lung fibroblast (Normal)

P0016093 One Frozen vial
EUR 520

Human Primary Gingival Fibroblast

T4102 5x10^5 cells / 1.0 ml Ask for price

Normal Human Primary Lung Fibroblast

T5516 5x10^5 cells / 1.0 ml
EUR 725

Rat Primary Pulmonary Fibroblasts

T4801 5x10^5 cells / 1.0 ml Ask for price

Primary Rat Thymic Fibroblasts (TF)

CSI036Ra01 5X10^5
EUR 780

Primary Rat Ovarian Fibroblasts (OF)

CSI138Ra01 5X10^5
EUR 780

Primary Rat Adrenal Fibroblasts (ADF)

CSI091Ra01 5X10^5
EUR 720

Primary Rat Prostate Fibroblasts (PF)

CSI144Ra01 5X10^5
EUR 780

Primary Rat Gingival Fibroblasts (GF)

CSI147Ra01 5X10^5
EUR 850

Primary Rat Pulmonary Fibroblasts (PF)

CSI034Ra01 5X10^5
EUR 780

Primary Rat Bladder Stromal Fibroblasts (BSF)

CSI066Ra01 5X10^5
EUR 720

Primary Rat Neonatal Dermal Fibroblasts (NDF)

CSI088Ra01 5X10^5
EUR 810

Human Primary Friedriech's Ataxia (FA) Fibroblast Cell Line 130

T5442 5x10^5 cells / 1.0 ml
EUR 975

Human Primary Friedriech's Ataxia (FA) Fibroblast Cell Line 6237

T5444 5x10^5 cells / 1.0 ml
EUR 975

Human Primary Friedriech's Ataxia (FA) Fibroblast Cell Line 281

T5446 5x10^5 cells / 1.0 ml
EUR 975

Human Primary Friedriech's Ataxia (FA) Fibroblast Cell Line 4090

T5448 5x10^5 cells / 1.0 ml
EUR 975

Human Primary Friedriech's Ataxia (FA) Fibroblast Cell Line 4743

T5477 5x10^5 cells / 1.0 ml
EUR 975

Human Primary Friedriech's Ataxia (FA) Fibroblast Cell Line 179

T5480 5x10^5 cells / 1.0 ml
EUR 975

Human Primary Uterine Fibroblasts

T4084 5x10^5 cells / 1.0 ml Ask for price

Human Primary Cardiac Fibroblasts

T4038 5x10^5 cells / 1.0 ml
EUR 1375

Canine Primary Dermal Fibroblasts

T0269 5x10^5 cells / 1.0 ml Ask for price

Mouse Primary Cardiac Fibroblasts

T4591 5x10^5 cells / 1.0 ml Ask for price

Mouse Primary Uterine Fibroblasts

T4630 5x10^5 cells / 1.0 ml
EUR 975

Human Primary Friedriech's Ataxia (FA) Fibroblast Cell Line 68

T5479 5x10^5 cells / 1.0 ml
EUR 975

Human Primary Tracheal Fibroblasts

T4005 5x10^5 cells / 1.0 ml Ask for price

Human Primary Neonatal Fibroblasts

T4104 5x10^5 cells / 1.0 ml Ask for price

Human Primary Friedriech's Ataxia (FA) Fibroblast Cell Line 4230B

T5478 5x10^5 cells / 1.0 ml
EUR 975

Human Primary Pulmonary Fibroblasts

T4009 5x10^5 cells / 1.0 ml
EUR 975

Human Primary Epidermal Fibroblasts

T0300 5x10^5 cells / 1.0 ml
EUR 625

Mouse Primary Pulmonary Fibroblasts

T4504 5x10^5 cells / 1.0 ml Ask for price

Human Primary Esophageal Fibroblasts

T4232 5x10^5 cells / 1.0 ml Ask for price

Primary Canine Thymic Fibroblasts (TF)

CSI036Ca01 5X10^5
EUR 980

Primary Mouse Splenic Fibroblasts (SF)

CSI094Mu01 5X10^5
EUR 780

Primary Rabbit Thyroid Fibroblasts (TF)

CSI040Rb01 5X10^5
EUR 860

Primary Canine Splenic Fibroblasts (SF)

CSI094Ca01 5X10^5
EUR 800

Primary Canine Ovarian Fibroblasts (OF)

CSI138Ca01 5X10^5
EUR 880

Primary Rabbit Ovarian Fibroblasts (OF)

CSI138Rb01 5X10^5
EUR 860

Primary Mouse Pulmonary Fibroblasts (PF)

CSI034Mu01 5X10^5
EUR 720

Primary Canine Pulmonary Fibroblasts (PF)

CSI034Ca01 5X10^5
EUR 1200

Primary Rabbit Pulmonary Fibroblasts (PF)

CSI034Rb01 5X10^5
EUR 820

Primary Caprine Pulmonary Fibroblasts (PF)

CSI034Cp01 5X10^5
EUR 950

Human Primary Bladder Stromal Fibroblasts

T4162 5x10^5 cells / 1.0 ml Ask for price

Human Primary Villous Mesenchymal Fibroblasts

T4112 5x10^5 cells / 1.0 ml Ask for price

Primary Mouse Bladder Stromal Fibroblasts (BSF)

CSI066Mu01 5X10^5
EUR 850

Primary Mouse Neonatal Dermal Fibroblasts (NDF)

CSI088Mu01 5X10^5
EUR 740

Human Primary Periodontal Ligament Fibroblasts

T4075 5x10^5 cells / 1.0 ml
EUR 975

Primary Canine Bladder Stromal Fibroblasts (BSF)

CSI066Ca01 5X10^5
EUR 980

Primary Rabbit Bladder Stromal Fibroblasts (BSF)

CSI066Rb01 5X10^5
EUR 850

Primary Canine Neonatal Dermal Fibroblasts (NDF)

CSI088Ca01 5X10^5
EUR 1160

Primary Caprine Bladder Stromal Fibroblasts (BSF)

CSI066Cp01 5X10^5
EUR 1130

Human Primary COPD Lung Parenchymal Fibroblasts

T5428 1 x 10^6 / 1.0 ml Ask for price

Human Synoviocyte Growth Medium

C0013-44 RT 500 mL Bottle
EUR 98

HighQC™ Human IPSC From Activated Fibroblast From Primary Keratocytes-Keratoconus

ABC-SC2092 1 vial Ask for price
Description: Cell Type iPSCPrimary Tissue Activated fibroblast from primary keratocytesReprogramming Method Episomal PlasmidDisease Keratoconus; Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

Human Primary Pulmonary Fibrosis Lung Parenchymal Fibroblasts

T5418 1 x 10^6 / 1.0 ml Ask for price

Human Primary DF508/DF508 Cystic Fibrosis Parenchymal Fibroblasts

T5422 5 x 10^5 / 1.0 ml Ask for price

Human Primary Idiopathic Pulmonary Fibrosis Lung Parenchymal Fibroblasts

T5419 1 x 10^6 / 1.0 ml Ask for price

Basic Nucleofector Kit for Primary Mammalian Fibroblasts, 25 reactions

LOVPI-1002 each
EUR 630.82

Basic Nucleofector Kit for Primary Mammalian Fibroblasts, 100 reactions

LOVVPI-1002 each Ask for price

Synoviocyte Growth Medium, Ready-to-Use, 500 ml, 10% Human Serum Supplement

M2700-10HS 500 ml bottle
EUR 120

Synoviocyte Growth Medium, Ready-to-Use, 500 ml, 2% Human Serum Supplement Factors

M2700-2HS 500 ml bottle
EUR 120

Human Primary Pulmonary Arterial Hypertension (PAH) Lung Parenchymal Fibroblasts

T5464 5 x 10^5 / 1.0 ml Ask for price

Primary Rabbit Synovial Cells (SYC)

CSI114Rb01 5X10^5
EUR 1150

Primary Rat Annulus Fibrosus Cells (AFC)

CSI008Ra01 5X10^5
EUR 870

Rat Fibroblast Growth Factor Receptor Like 1 (FGFRL1) ELISA Kit

abx391334-96tests 96 tests
EUR 1093.2

Rat Fibroblast Growth Factor Receptor Like 1 (FGFRL1) ELISA Kit

abx391334-100l 100 µl Ask for price

Rat Fibroblast Growth Factor Receptor Like 1 (FGFRL1) ELISA Kit

abx391334-50l 50 µl
EUR 687.5

Rat Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS076000-10x96StripWells 10x96-Strip-Wells
EUR 6725

Rat Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS076000-48StripWells 48-Strip-Wells
EUR 550

Rat Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS076000-5x96StripWells 5x96-Strip-Wells
EUR 3420

Rat Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS076000-96StripWells 96-Strip-Wells
EUR 765

Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Protein

20-abx066618
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Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Protein

abx066618-100g 100 µg
EUR 600

Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Protein

abx066618-10g 10 µg
EUR 225

Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Protein

abx066618-50g 50 µg
EUR 412.5

Immortalized Human Synovial Membrane Fibroblasts-SV40

CSC-I9106L One Frozen vial Ask for price

Rat Lung PrimaCell1: Normal Lung Fibroblasts

2-82564 1 Kit Ask for price

Rat Brain PrimaCell1: Normal Brain Fibroblasts

2-82511 1 Kit Ask for price

Rat Eye PrimaCell3: Normal Corneal Fibroblasts

2-82540 1 Kit Ask for price

Rat Heart PrimaCell3: Normal Heart Fibroblasts

2-82548 1 Kit Ask for price

Rat Lung Fibroblast

CP-R006 5×105 cells/vial
EUR 550
Description: Rat

Rat Renal Fibroblast

CP-R069 5×105 cells/vial
EUR 550
Description: Rat

Rat Bladder PrimaCell2: Normal Bladder Fibroblasts

2-82507 1 Kit Ask for price

Rat Cervix PrimaCell2: Normal Cervical Fibroblasts

2-82525 1 Kit Ask for price

Rat Lymph PrimaCell3: Normal Lymphatic Fibroblasts

2-82572 1 Kit Ask for price

Rat Dermal Fibroblast

CP-R086 5×105 cells/vial
EUR 550
Description: Rat

Rat ; Rat embryonic fibroblast

02-705 100ng
EUR 481.2
Description: The Rat ; Rat embryonic fibroblast is available in Europe and for worldwide shipping via Gentaur.

Rat Bladder Fibroblast

CP-R066 5×105 cells/vial
EUR 550
Description: Rat

Rat Embryo PrimaCell2: Normal Fetal Dermal Fibroblasts

2-82532 1 Kit Ask for price

Rat Embryonic Fibroblast

CP-R175 5×105 cells/vial
EUR 550
Description: Rat

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Polyclonal Antibody (Rat)

4-PAL113Ra01
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Description: A Rabbit polyclonal antibody against Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1)

Rat Lung PrimaCell3: Normal Pulmonary Artery Fibroblasts

2-82566 1 Kit Ask for price

Rat Lung PrimaCell1: Normal Lung Fibroblasts Growth Medium

9-25064 5 x 100 ml Ask for price

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Polyclonal Antibody (Rat), APC

4-PAL113Ra01-APC
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Description: A Rabbit polyclonal antibody against Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1). This antibody is labeled with APC.

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Polyclonal Antibody (Rat), Cy3

4-PAL113Ra01-Cy3
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Description: A Rabbit polyclonal antibody against Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1). This antibody is labeled with Cy3.

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Polyclonal Antibody (Rat), HRP

4-PAL113Ra01-HRP
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Description: A Rabbit polyclonal antibody against Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1). This antibody is labeled with HRP.

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Polyclonal Antibody (Rat), PE

4-PAL113Ra01-PE
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Description: A Rabbit polyclonal antibody against Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1). This antibody is labeled with PE.

Rat Brain PrimaCell1: Normal Brain Fibroblasts Growth Medium

9-25011 5 x 100 ml Ask for price

Rat Eye PrimaCell3: Normal Corneal Fibroblasts Growth Medium

9-25040 5 x 100 ml Ask for price

Rat Heart PrimaCell3: Normal Heart Fibroblasts Growth Medium

9-25048 5 x 100 ml Ask for price

Fibroblast Growth Factor Receptor Like 1 (FGFRL1) Antibody

abx026978-400ul 400 ul
EUR 627.6

Fibroblast Growth Factor Receptor Like 1 (FGFRL1) Antibody

abx026978-80l 80 µl
EUR 343.2

Fibroblast Growth Factor Receptor Like 1 (FGFRL1) Antibody

abx026978-400l 400 µl
EUR 518.75

Rat Bone Marrow Fibroblast

ABC-TC4084 1 vial Ask for price
Description: Rat bone marrow fibroblasts, 3-week Wistar rat

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Polyclonal Antibody (Rat), FITC

4-PAL113Ra01-FITC
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Description: A Rabbit polyclonal antibody against Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1). This antibody is labeled with FITC.

Rat Bladder PrimaCell2: Normal Bladder Fibroblasts Growth Medium

9-25007 5 x 100 ml Ask for price

Rat Cervix PrimaCell2: Normal Cervical Fibroblasts Growth Medium

9-25025 5 x 100 ml Ask for price

Rat Lymph PrimaCell3: Normal Lymphatic Fibroblasts Growth Medium

9-25072 5 x 100 ml Ask for price

Recombinant Fibroblast growth factor 19-like (FGF19) for pig

MBS7054835-005mgBaculovirus 0.05mg(Baculovirus)
EUR 1035

Recombinant Fibroblast growth factor 19-like (FGF19) for pig

MBS7054835-005mgEColi 0.05mg(E-Coli)
EUR 695

Recombinant Fibroblast growth factor 19-like (FGF19) for pig

MBS7054835-005mgYeast 0.05mg(Yeast)
EUR 870

Recombinant Fibroblast growth factor 19-like (FGF19) for pig

MBS7054835-02mgEColi 0.2mg(E-Coli)
EUR 925

Recombinant Fibroblast growth factor 19-like (FGF19) for pig

MBS7054835-05mgEColi 0.5mg(E-Coli)
EUR 1015

Rat Embryo PrimaCell2: Normal Fetal Dermal Fibroblasts Growth Medium

9-25032 5 x 100 ml Ask for price

Rat Ariway PrimaCell3: Normal Bronchial and and Tracheal Fibroblasts

2-82503 1 Kit Ask for price

Primary Mouse Annulus Fibrosus Cells (AFC)

CSI008Mu01 5X10^5
EUR 850

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Polyclonal Antibody (Rat), Biotinylated

4-PAL113Ra01-Biotin
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Description: A Rabbit polyclonal antibody against Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1). This antibody is labeled with Biotin.

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Polyclonal Antibody (Rat), APC-Cy7

4-PAL113Ra01-APC-Cy7
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Description: A Rabbit polyclonal antibody against Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1). This antibody is labeled with APC-Cy7.

HighQC™ Human IPSC From Fibroblast-Huntington's Disease Like

ABC-SC2091 1 vial Ask for price
Description: Cell Type iPSCPrimary Tissue FibroblastReprogramming Method Episomal PlasmidDisease Huntington's Disease Like; Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

Rat Lung PrimaCell3: Normal Pulmonary Artery Fibroblasts Growth Medium

9-25066 5 x 100 ml Ask for price

Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody Pair Kit (with Standard)

MBS2104218-10x96Tests 10x96Tests
EUR 1595

Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody Pair Kit (with Standard)

MBS2104218-10x96TestsMBS2090685AbPairsSupportPack110x96Tests 10x96Tests+MBS2090685(AbPairsSupportPack1,10x96Tests)
EUR 1715

Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody Pair Kit (with Standard)

MBS2104218-5x96Tests 5x96Tests
EUR 1005

Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody Pair Kit (with Standard)

MBS2104218-5x96TestsMBS2090685AbPairsSupportPack15x96Tests 5x96Tests+MBS2090685(AbPairsSupportPack1,5x96Tests)
EUR 1080

Cat Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS102465-INQUIRE INQUIRE Ask for price

Mouse Fibroblast Growth Factor Receptor Like 1 (FGFRL1) ELISA Kit

abx389293-96tests 96 tests
EUR 1093.2

Goat Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS097676-INQUIRE INQUIRE Ask for price

Cavy Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS048102-INQUIRE INQUIRE Ask for price

Duck Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS053445-INQUIRE INQUIRE Ask for price

Fish Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS064131-INQUIRE INQUIRE Ask for price

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

20-abx104527
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Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

20-abx104528
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Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

20-abx104529
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Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

20-abx213762
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Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

20-abx172426
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  • 1 mg
  • 200 ug

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

20-abx334166
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Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

20-abx325588
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Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx331774-100ul 100 ul
EUR 510

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

20-abx241098
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Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx172426-100l 100 µl
EUR 875

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx172426-1ml 1 ml Ask for price

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx172426-200l 200 µl Ask for price

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx213762-100l 100 µl
EUR 250

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx241098-100l 100 µl
EUR 350

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx241098-50l 50 µl
EUR 250

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx325588-100g 100 µg
EUR 250

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx325588-50g 50 µg
EUR 187.5

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx334166-100g 100 µg
EUR 362.5

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx334166-20g 20 µg
EUR 162.5

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx334166-50g 50 µg
EUR 250

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx104527-100g 100 µg
EUR 825

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx104527-20g 20 µg
EUR 287.5

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx104527-50g 50 µg
EUR 362.5

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx104528-100g 100 µg
EUR 850

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx104528-20g 20 µg
EUR 287.5

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx104528-50g 50 µg
EUR 375

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx104529-100g 100 µg
EUR 900

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx104529-20g 20 µg
EUR 300

Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Antibody

abx104529-50g 50 µg
EUR 387.5

Recombinant Rat Fibroblast Growth Factor 2/Fibroblast Growth Factor Basic Protein

MBS2553662-001mg 0.01mg
EUR 180

Recombinant Rat Fibroblast Growth Factor 2/Fibroblast Growth Factor Basic Protein

MBS2553662-005mg 0.05mg
EUR 380

Recombinant Rat Fibroblast Growth Factor 2/Fibroblast Growth Factor Basic Protein

MBS2553662-5x005mg 5x0.05mg
EUR 1690

Horse Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS095296-10x96StripWells 10x96-Strip-Wells
EUR 6725

Horse Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS095296-48StripWells 48-Strip-Wells
EUR 550

Horse Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS095296-5x96StripWells 5x96-Strip-Wells
EUR 3420

Horse Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS095296-96StripWells 96-Strip-Wells
EUR 765

Sheep Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS095849-10x96StripWells 10x96-Strip-Wells
EUR 6725

Sheep Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS095849-48StripWells 48-Strip-Wells
EUR 550

Sheep Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS095849-5x96StripWells 5x96-Strip-Wells
EUR 3420

Sheep Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS095849-96StripWells 96-Strip-Wells
EUR 765

Goose Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS050813-INQUIRE INQUIRE Ask for price

Mouse Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS051239-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS051239-48StripWells 48-Strip-Wells
EUR 550

Mouse Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS051239-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS051239-96StripWells 96-Strip-Wells
EUR 765

Human Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS063141-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS063141-48StripWells 48-Strip-Wells
EUR 550

Human Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS063141-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS063141-96StripWells 96-Strip-Wells
EUR 765

Camel Fibroblast Growth Factor Receptor Like Protein 1 ELISA Kit

MBS083491-10x96StripWells 10x96-Strip-Wells
EUR 6725

These findings suggest that oxidative stress associated upregulation and activation mst1 promote mitochondrial dysfunction and apoptosis in RA-FLSs by inhibiting AMPK-SIRT1 pathway signaling. This shows mst1 axis-AMPK-SIRT1 is a potential target for the treatment of RA.

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