Lnc RNA ZFAS1 regulates the proliferation, apoptosis, inflammatory response and autophagy of fibroblast-like synoviocytes via miR-2682-5p/ADAMTS9 axis in Rheumatoid Arthritis

Background: Rheumatoid arthritis (RA) is an autoimmune disease often. Emerging evidence suggests that antisense ZNFX1 RNA1 (ZFAS1) participate in physiological and pathological processes in RA. However, knowledge ZFAS1 in RA is limited, the potential paths ZFAS1 work needs to be investigated further.


Methods: Levels ZFAS1, microRNA (mir) -2682-5p, and ADAM metallopeptidase with thrombospondin type 1 motif 9 (ADAMTS9) were estimated using real-time quantitative polymerase chain reaction (qRT-PCR) assay. 3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide (MTT) assay was performed to explore the capabilities of cell proliferation in fibroblast-like synoviocytes (FLS-RA). Cell apoptosis was measured by flow cytometry. Also, the rate ADAMTS9, a protein associated with apoptosis, Cleaved-caspase-3 (active large subunit), and autophagy-related protein identified adopt western blot. Enzyme-linked immunosorbent assay (ELISA) was conducted to determine the production of inflammatory cytokines. In addition, the relationship between miR-2682-5p and ZFAS1 or ADAMTS9 verified utilize dual-luciferase reporter assay.


Results: High levels of ZFAS1 and ADAMTS9, and low levels of miR-2682-5p were observed in RA synovial tissue and FLS-RA. Knockdown of ZFAS1 cause a reduction of cell proliferation, inflammation, autophagy, and increased apoptosis in RA-FLS, while this effect was abolished by getting back in the inhibition of miR-2682-5p. In addition, miR-2682-5p effect on the phenotype of cells and the inflammatory response was eliminated by ADAMTS9 upregulation in RA-FLS. Mechanically, ZFAS1 given its role through miR-2682-5p / ADAMTS9 axis in RA.


Conclusion: ZFAS1 / miR-2682-5p / ADAMTS9 axis can modulate the behavior of cells, the inflammatory response in RA-FLS, may provide potential therapeutic targets for the treatment of RA.
Keywords: Rheumatoid arthritis; cell autophagy; inflammatory.

 Lnc RNA ZFAS1 regulates the proliferation, apoptosis, inflammatory response and autophagy of fibroblast-like synoviocytes via miR-2682-5p/ADAMTS9 axis in Rheumatoid Arthritis
Lnc RNA ZFAS1 regulates the proliferation, apoptosis, inflammatory response and autophagy of fibroblast-like synoviocytes via miR-2682-5p/ADAMTS9 axis in Rheumatoid Arthritis

Estrogen downregulates the expression of TAK1 in human fibroblast-like synoviocytes and models of rheumatoid arthritis

Transforming growth factor-β-activated kinase 1 (TAK1), a member of the protein kinase family of mitogen-activated, plays a key role in the pathogenesis and progression of rheumatoid arthritis (RA). Estrogen has been reported previously to delay the progression of arthritis. However, the exact association between TAK1 and estrogen remains elusive. This study demonstrated that TAK1 synoviocytes is upregulated in patients with RA compared to patients with osteoarthritis and healthy controls. In addition, the TAK1 also expressed in cultured fibroblast-like synoviocytes (FLS), and the levels were decreased significantly in 17β-estradiol (E2) -treated cells in a dose-dependent manner

. In addition, administration of E2 significantly decreased expression of TAK1 and attenuated the development of collagen-induced arthritis (CIA). Taken together, the findings from this study suggest that E2 mediates TAK1 decline in both FLS and the CIA, which later resulted in the suppression of pathological processes CIA. Therefore, estrogen may serve as a potential therapeutic agent for the treatment of RA by targeting TAK1.

Human Cryopreserved Bone Cells, RA

CDD-H-2810-RA 1 vial
EUR 600

Human Cryopreserved Tendon Cells

CDD-H-2465 1 vial
EUR 575

Pooled Human Semen Cryopreserved

IRHUSMCRYP0.5ML each
EUR 1170
Description: Pooled Human Semen Cryopreserved

Human Cryopreserved Bone Cells, OA

CDD-H-2810-OA 1 vial
EUR 600

Human Cryopreserved Chondrocytes, OA

CDD-H-2610-OA 1 vial
EUR 575

Human Cryopreserved Bone Cells, Normal

CDD-H-2810-N 1 vial
EUR 600

Human Cryopreserved Ligament Cells, ACL

CDD-H-2475-ACL 1 vial
EUR 575

Human Cryopreserved Ligament Cells, PCL

CDD-H-2475-PCL 1 vial
EUR 575

Human Cryopreserved Chondrocytes, Normal

CDD-H-2610-N 1 vial
EUR 575

Human Cryopreserved Dermal Fibroblast Cells

CDD-H-2510 1 vial
EUR 575

Human Synoviocytes

ABC-TC3829 1 vial Ask for price
Description: Human synoviocytes (HS), the predominant cell type of healthy synovial tissue, are fibroblast-like cells. The Synoviocytes form a distinct structure called the synovial lining layer. Electron microscopy revealed extensive cell-to-cell contacts within the lining layer. The Synoviocytes produce synovial fluid components and are responsible for absorption from the joint cavity, and for blood/synovial fluid exchanges. The synoviocytes proliferate, show anchorage-independent growth, and also secrete a variety of effector molecules that promote inflammation and joint destruction and, themselves are part of a complex network of autocrine and paracrine acting factors. The synoviocytes express cadherin-11 providing new insight into synovial tissue organization and morphogenesis and of interest as a therapeutic target.HS from Gentaur Research Laboratories are isolated from human synovium. HS are cryopreserved at passage one cultures and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HS are characterized by their fibroblast-like morphology, growth pattern and immunocytochemistry of CD 90 and fibronectin. HS are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HS are guaranteed for 15 population doublings at the conditions provided by Gentaur Research Laboratories.

Human CD3+ T Cells (Pan T Cells), Cryopreserved

M1299-10 each Ask for price

Human CD3+ T Cells (Pan T Cells), Cryopreserved

M1299-20 each Ask for price

Human CD3+ T Cells (Pan T Cells), Cryopreserved

M1299-30 each Ask for price

Human CD3+ T Cells (Pan T Cells), Cryopreserved

M1299-40 each Ask for price

Rat Cryopreserved Chondrocytes, P2

CDD-R-2610 1 vial
EUR 575

Human fibroblast-like synoviocytes: Rheumatoid Arthritis (HFLS-RA)

P0004019 One Frozen vial
EUR 700

Human Fibroblast-Like Synoviocytes

cAP-0141 1Frozen Vial
EUR 693

Immortalized Human Synoviocytes-SV40

CSC-I2279Z One Frozen vial Ask for price

Synoviocytes Growth Medium

cAP-68 500ml
EUR 148.5

Human fibroblast-like synoviocytes (HFLS)

P0004018 One Frozen vial
EUR 700

Human Cryopreserved Intervertebral Disc Cells, Healthy Donor: Annulus Fibrosus (AF)

CDD-H-2710-AF 1 vial
EUR 575

Human Cryopreserved Intervertebral Disc Cells, Healthy Donor: Nucleus Pulposus (NP)

CDD-H-2710-NP 1 vial
EUR 575

Positively Selected Normal Peripheral Blood CD19+ B Cells, Cryopreserved

PBCD19P-C10M - Ask for price

Immortalized Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes-hTERT

CSC-I2074Z One Frozen vial Ask for price

Epithelial Cryopreserve Media

FM301 each
EUR 259.2

Human Synoviocyte Growth Medium

C0013-44 RT 500 mL Bottle
EUR 98

Cryopreservation Medium For Human Embryonic Stem Cells

HUXES-07031 20/50mL Ask for price

CRYOPRESERVATION BAG, 50ML

91-200-88 1/pk
EUR 97.2
Description: Flexible Containers; Bioprocess Bags and Parts

CRYOPRESERVATION BAG, 250ML

91-200-89 1/pk
EUR 100.8
Description: Flexible Containers; Bioprocess Bags and Parts

CRYOPRESERVATION BAG, 500ML

91-200-90 1/pk
EUR 104.4
Description: Flexible Containers; Bioprocess Bags and Parts

CRYOPRESERVATION BAG, 750ML

91-200-91 1/pk
EUR 108
Description: Flexible Containers; Bioprocess Bags and Parts

Cryopreservation Medium

TM024 100ml
EUR 175

Serum Free Cryopreservation Medium

TM026 25 ml
EUR 50

Waymouth Cryopreservation Medium

0459 100 ml
EUR 21.8

AddexBio Cryopreservation Medium

C0002-01-20mL RT vial
EUR 25

AddexBio Cryopreservation Medium

C0002-20mL RT vial
EUR 124.8

Cryopreservation Medium For General Use

CYRO-10001 20/50mL Ask for price

NCR Cryopreservation Medium For General Use

NCRC-10001 20/50mL Ask for price

Human Fibroblast-Like Synoviocyte Normal Tissue, Adult

ABC-TC3619 1 vial Ask for price
Description: Human Fibroblast-Like Synoviocytes (HFLS) are isolated from normal synovial tissues. They are cryopreserved at second passage and can be cultured and propagated at least 5 population doublings.

Cryopreservation Medium For Neural Stem Cells

GUXNX-07031 20/50mL Ask for price

Human Fibroblast-Like Synoviocyte Osteo Arthritis, Adult

ABC-TC3620 1 vial Ask for price
Description: Human Fibroblast-Like Synoviocytes (HFLS) are isolated from synovial tissues obtained from patients with Rheumatoid Arthritis (RA) / Osteoarthritis (OA). They are cryopreserved at second passage and can be cultured and propagated at least 5 population doubling.

Serum-free cell cryopreservation solution

EGQA0073 100ml
EUR 80

Synoviocyte Growth Medium, Ready-to-Use, 500 ml, 10% Human Serum Supplement

M2700-10HS 500 ml bottle
EUR 120

Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult

ABC-TC3621 1 vial Ask for price
Description: Human Fibroblast-Like Synoviocytes (HFLS) are isolated from synovial tissues obtained from patients with Rheumatoid Arthritis (RA) / Osteoarthritis (OA). They are cryopreserved at second passage and can be cultured and propagated at least 5 population doubling.

NCR Protein-Free Cryopreservation Medium For General Use

NCPF-10001 20/50mL Ask for price

Synoviocyte Growth Medium, Ready-to-Use, 500 ml, 2% Human Serum Supplement Factors

M2700-2HS 500 ml bottle
EUR 120

Chemical Defined Xeno-free Cell Cryopreservation Medium

abx298009-20ml 20 ml
EUR 292.8

QuickFreezing-I Insect cell cryopreservation solution

E28X0310043-100 100ml
EUR 361.9

NCR Protein-Free Cryopreservation Medium For Neural Stem Cells

GUXNX-07021 20/50mL Ask for price

QuickFreezing-M Mammalian cell cryopreservation solution

E28X0310041-100 100ml
EUR 184.13

QuickFreezing-M Mammalian cell cryopreservation solution

E28X0310041-30 30ml
EUR 69.84

QuickFreezing-2×M Mammalian cell cryopreservation solution

E28X0310042-100 100ml
EUR 361.9

QuickFreezing-2×M Mammalian cell cryopreservation solution

E28X0310042-30 30ml
EUR 133.33

COOLCELL SV2 STEMCELL CRYOPRESERVATION SYSTEM INCLUDES THE XT STARTER BENCHTOP COOLER, COOLRACK SV2 AND COOLCELL SV2 CELL FREEZING CONTAINER FOR 12 INJECTABLE VIALS

432012 1/pk
EUR 1024.8
Description: BioCision; BioCision CoolCell

COOLCELL SV10 STEMCELL CRYOPRESERVATION SYSTEM INCLUDES THE XT STARTER BENCHTOP COOLER, COOLRACK SV10 AND COOLCELL SV10 CELL FREEZING CONTAINER FOR 6 INJECTABLE VIALS

432013 1/pk
EUR 1024.8
Description: BioCision; BioCision CoolCell

Human Synovial Fluid, RA

CDD-H-5000-RA 0.5 ml
EUR 300

Human Synovial Tissue, RA, FFPE

CDD-H-3000-ST-RA 1 H-E stained slide, 2 unstained slides
EUR 200

Human Synovial Tissue, Fresh, RA

CDD-H-6300-RA-5G-FRESH 5g
EUR 800

Human Synovial Tissue, RA, RNALater

CDD-H-6300-RA-1G-R 1g
EUR 250

Human Synovial Tissue, RA, OCT frozen

CDD-H-3000-OCT-ST-RA Flash frozen tissue in OCT medium
EUR 250

Human Synovial Tissue, RA, Snap Frozen

CDD-H-6300-RA-1G-F 1g
EUR 250

Human Synovial Tissue Explant Culture, RA

CDD-H-2920-RA Multiwell plate format
EUR 675

Human synovial apoptosis inhibitor 1, synoviolin(SYVN1) ELISA Kit

NSL2294Hu 96 wells
EUR 468

Total RNA - Human Tumor Tissue: Synoviosarcoma

R1235257-10 10 ug
EUR 480

Total Protein - Human Tumor Tissue: Synoviosarcoma

P1235257 1 mg
EUR 542

Human E3 ubiquitin- protein ligase synoviolin, SYVN1 ELISA KIT

ELI-29339h 96 Tests
EUR 988.8

SYVN1 (untagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1

SC324298 10 µg Ask for price

SYVN1 (untagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2

SC101046 10 µg Ask for price

SYVN1 (untagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1

SC309770 10 µg Ask for price

Human E3 ubiquitin-protein ligase synoviolin(SYVN1) Elisa Kit

EK713836 96 Wells
EUR 0.4

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

EK6825 96Т
EUR 799

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

abx383609-96tests 96 tests
EUR 1093.2

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

AE16187HU-48Tests 48 Tests
EUR 325
Description: Human (Homo sapiens)

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

AE16187HU-96Tests 96 Tests
EUR 610
Description: Human (Homo sapiens)

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

KTE60446-48T 48T
EUR 339
Description: This Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

KTE60446-96T 96T
EUR 589
Description: This Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

KTE60446-96T5 96 T×5
EUR 2629
Description: This Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

KTE60446-96T50 96 T×50
EUR 24569
Description: This Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.

Human E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) ELISA Kit

abx383609-1096tests 10 × 96 tests Ask for price

Human E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) ELISA Kit

abx383609-596tests 5 × 96 tests Ask for price

SYVN1 (GFP-tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1

RG207132 10 µg Ask for price

SYVN1 (GFP-tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2

RG220540 10 µg Ask for price

ELISA kit for Human E3 ubiquitin-protein ligase synoviolin (SYVN1)

KTE60446-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Human E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

SYVN1 (Myc-DDK-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2

RC220540 10 µg Ask for price

SYVN1 (Myc-DDK-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1

RC207132 10 µg Ask for price

Human E3 ubiquitin-Protein Ligase synoviolin, SYVN1 GENLISA ELISA

KBH5217 1 x 96 wells
EUR 286

Lenti ORF clone of Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, mGFP tagged

RC220540L2 10 µg Ask for price

Lenti ORF clone of Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, mGFP tagged

RC220540L4 10 µg Ask for price

Lenti ORF clone of Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, Myc-DDK-tagged

RC220540L1 10 µg Ask for price

Lenti ORF clone of Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, Myc-DDK-tagged

RC220540L3 10 µg Ask for price

Lenti-ORF clone of SYVN1 (mGFP-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1

RC207132L4 10 µg Ask for price

Lenti-ORF clone of SYVN1 (Myc-DDK-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1

RC207132L3 10 µg Ask for price

Lenti ORF particles, SYVN1 (mGFP-tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, 200ul, >10^7 TU/mL

RC220540L2V 200 µl Ask for price

Lenti ORF particles, SYVN1 (mGFP-tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, 200ul, >10^7 TU/mL

RC220540L4V 200 µl Ask for price

Lenti ORF particles, SYVN1 (mGFP-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1, 200ul, >10^7 TU/mL

RC207132L4V 200 µl Ask for price

Lenti ORF particles, SYVN1 (Myc-DDK tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, 200ul, >10^7 TU/mL

RC220540L1V 200 µl Ask for price

Lenti ORF particles, SYVN1 (Myc-DDK tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, 200ul, >10^7 TU/mL

RC220540L3V 200 µl Ask for price

Lenti ORF particles, SYVN1 (Myc-DDK-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1, 200ul, >10^7 TU/mL

RC207132L3V 200 µl Ask for price

Synovial Apoptosis Inhibitor 1, Synoviolin Antibody

20-abx115960
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  • 150 ul
  • 50 ul

Synovial Apoptosis Inhibitor 1, Synoviolin Antibody

abx115960-100g 100 µg Ask for price

Synovial Apoptosis Inhibitor 1, Synoviolin Antibody

abx115960-10g 10 µg
EUR 612.5

Synovial Apoptosis Inhibitor 1, Synoviolin Antibody

abx115960-200g 200 µg Ask for price

Human Synovial Tissue Explant Culture, RA with wet weight determination provided for each explant in Excel spreadsheet

CDD-H-2920-RA-WW Multiwell plate format
EUR 875

Syvn1 (untagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), (10 ug)

RN210996 10 µg Ask for price

Syvn1 (GFP-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1)

MG209408 10 µg Ask for price

Syvn1 (Myc-DDK-tagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), (10 ug)

RR210996 10 µg Ask for price

Lenti ORF clone of Syvn1 (mGFP-tagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), (10 ug)

RR210996L4 10 µg Ask for price

Lenti ORF clone of Syvn1 (Myc-DDK-tagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), (10 ug)

RR210996L3 10 µg Ask for price

Human Synovial Fluid

ABC-TC3824 1 vial Ask for price
Description: Human synovial tissue and fluid are isolated from a single donor. This fluid has been frozen fresh. Synovial tissue and fluid can enable your knowledge of disease mechanisms and allows you to correlate clinical symptoms with pathology. Most importantly these observations may lead to the discovery of new therapeutic targets in arthritis disease.Development period: Postnatal

Syvn1 (untagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1, (10ug)

MC204599 10 µg Ask for price

Lenti ORF particles, Syvn1 (Myc-DDK-tagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), 200ul, >10^7 TU/mL

RR210996L3V 200 µl Ask for price

Lenti ORF particles, Syvn1 (GFP-tagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), 200ul, >10^7 TU/mL

RR210996L4V 200 µl Ask for price

Syvn1 (GFP-tagged) - Mouse synovial apoptosis inhibitor 1 synoviolin (Syvn1) transcript variant 2, (10ug)

MG219322 10 µg Ask for price

Human Synovial Fluid, OA

CDD-H-5000-OA 0.5 ml
EUR 300

Mouse E3 ubiquitin- protein ligase synoviolin, Syvn1 ELISA KIT

ELI-23703m 96 Tests
EUR 1038

E3 Ubiquitin-Protein Ligase Synoviolin (HRD1) Antibody

abx031572-400ul 400 ul
EUR 627.6

E3 Ubiquitin-Protein Ligase Synoviolin (HRD1) Antibody

abx031572-80l 80 µl
EUR 343.2

E3 Ubiquitin-Protein Ligase Synoviolin (HRD1) Antibody

abx031572-400l 400 µl
EUR 518.75

CryoProtX

M-MD1-61 46 x 1.5 ml ml
EUR 360
Description: CryoProtX

Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1

MR209408 10 µg Ask for price

Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 2

MR219322 10 µg Ask for price

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx431931-200ul 200 ul
EUR 460.8

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx431932-200ul 200 ul
EUR 460.8

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

20-abx302155
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  • 100 ug
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E3 ubiquitin-protein ligase synoviolin (SYVN1) Antibody

20-abx211798
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  • 100 ul
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E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx238463-100ug 100 ug
EUR 610.8

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

20-abx002034
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  • 100 ul
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E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx025097-400ul 400 ul
EUR 627.6

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx025097-80l 80 µl
EUR 343.2

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx025098-400ul 400 ul
EUR 627.6

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx025098-80l 80 µl
EUR 343.2

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx002034-100l 100 µl
EUR 400

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx002034-20l 20 µl
EUR 175

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx002034-50l 50 µl
EUR 275

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx302155-100g 100 µg
EUR 362.5

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx302155-20g 20 µg
EUR 162.5

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx302155-50g 50 µg
EUR 250

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx025097-400l 400 µl
EUR 518.75

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx025098-400l 400 µl
EUR 518.75

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx238463-100g 100 µg
EUR 350

E3 ubiquitin-protein ligase synoviolin (SYVN1) Antibody

abx211798-100l 100 µl
EUR 350

E3 ubiquitin-protein ligase synoviolin (SYVN1) Antibody

abx211798-50l 50 µl
EUR 250

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx431931-100g 100 µg
EUR 387.5

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx431932-100g 100 µg
EUR 387.5

Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

EK6826 96Т
EUR 799

Syvn1 ELISA Kit| Mouse E3 ubiquitin-protein ligase synoviolin E

EF016338 96 Tests
EUR 826.8

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (HRP)

20-abx314566
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

abx390695-96tests 96 tests
EUR 1093.2

Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

AE16188MO-48Tests 48 Tests
EUR 325
Description: Mouse (Mus musculus)

Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

AE16188MO-96Tests 96 Tests
EUR 610
Description: Mouse (Mus musculus)

Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

KTE70316-48T 48T
EUR 339
Description: This Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.

Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

KTE70316-96T 96T
EUR 589
Description: This Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.

Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

KTE70316-96T5 96 T×5
EUR 2629
Description: This Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.

Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

KTE70316-96T50 96 T×50
EUR 24569
Description: This Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.

Mouse E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) ELISA Kit

abx390695-1mg 1 mg
EUR 687.5

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (HRP)

abx314566-100g 100 µg
EUR 362.5

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (HRP)

abx314566-20g 20 µg
EUR 162.5

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (HRP)

abx314566-50g 50 µg
EUR 250

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (FITC)

20-abx314567
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

ELISA kit for Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1)

KTE70316-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (FITC)

abx314567-100g 100 µg
EUR 362.5

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (FITC)

abx314567-20g 20 µg
EUR 162.5

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (FITC)

abx314567-50g 50 µg
EUR 250

3`UTR clone of synovial apoptosis inhibitor 1 synoviolin (SYVN1) transcript variant 1 for miRNA target validation

SC212618 10 µg Ask for price

3`UTR clone of synovial apoptosis inhibitor 1 synoviolin (SYVN1) transcript variant 2 for miRNA target validation

SC212619 10 µg Ask for price

Lenti ORF clone of Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1

MR209408L3 10 µg Ask for price

Lenti ORF clone of Syvn1 (mGFP-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1

MR209408L4 10 µg Ask for price

Lenti ORF clone of Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 2

MR219322L3 10 µg Ask for price

Lenti ORF clone of Syvn1 (mGFP-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 2

MR219322L4 10 µg Ask for price

Human Synovial Fluid, Normal

CDD-H-5000-N 0.5 ml
EUR 300

Human Synovial Tissue, OA, FFPE

CDD-H-3000-ST-OA 1 H-E stained slide, 2 unstained slides
EUR 200

Human Synovial Stromal Cells

ABC-TC3826 1 vial Ask for price
Description: Primary Human Synovial Stromal Cells were initiated by elutriation from normal human synovial tissue.These cells were originated using Complete Serum-Free Medium Kit With AcceSup™, are available at <12 Cumulative Population Doublings (CPD) in vitro [Passage 3] and were cryopreserved in aliquots of ~1.5×10^6 cells. This vial will initiate a Passage 4 cell culture in a 75cm2 flask.

Human Synovial Tissue, Fresh, OA

CDD-H-6300-OA-5G-FRESH 5g
EUR 800

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (Biotin)

20-abx314568
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (Biotin)

abx314568-100g 100 µg
EUR 362.5

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (Biotin)

abx314568-20g 20 µg
EUR 162.5

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (Biotin)

abx314568-50g 50 µg
EUR 250

Lenti ORF particles, Syvn1 (GFP-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1, 200ul, >10^7 TU/mL

MR209408L4V 200 µl Ask for price

Lenti ORF particles, Syvn1 (GFP-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 2, 200ul, >10^7 TU/mL

MR219322L4V 200 µl Ask for price

CryoProtX Eco Screen

M-MD1-61-ECO 46 x 1.5 ml ml
EUR 360
Description: CryoProtX Eco Screen

Human Synovial Tissue, OA, OCT frozen

CDD-H-3000-OCT-ST-OA Flash frozen tissue in OCT medium
EUR 250

Single Donor Human Synovial Fluid

IRHUSYNS1ML each
EUR 427
Description: Single Donor Human Synovial Fluid

Human Synovial Tissue, Normal, FFPE

CDD-H-3000-ST-N 1 H-E stained slide, 2 unstained slides
EUR 200

Human Synovial Tissue, OA, RNALater

CDD-H-6300-OA-1G-R 1g
EUR 250

Lenti ORF particles, Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1, 200ul, >10^7 TU/mL

MR209408L3V 200 µl Ask for price

Lenti ORF particles, Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 2, 200ul, >10^7 TU/mL

MR219322L3V 200 µl Ask for price

CryoProtX Mix Reagents 1.5 mL

M-MDSR-61 1.5 ml ml
EUR 37
Description: CryoProtX Mix Reagents 1.5 mL

Human Synovial Tissue, OA, Snap Frozen

CDD-H-6300-OA-1G-F 1g
EUR 250

Human Synovial Tissue, Fresh, Normal

CDD-H-6300-N-5G-FRESH 5g
EUR 800


Since this article has been alleged infringement and corresponding study author did not respond to our request to prove the authenticity of the data and figures, “Mir-20a Regulates fibroblast-like synoviocyte proliferation and apoptosis in rheumatoid arthritis, by X.-J. Wei, X.- W. Li, J.-L. Lu, long Z.-X., J.-Q. Liang, S.-B. Wei, C.-X. Lu, Lu W.-Z., published in Eur Rev Med Pharmacol Sci 2017; 21 (17): 3886-3893-PMID: 28,975,975 “has been withdrawn. Publisher apologizes for any inconvenience this may cause.