Lnc RNA ZFAS1 regulates the proliferation, apoptosis, inflammatory response and autophagy of fibroblast-like synoviocytes via miR-2682-5p/ADAMTS9 axis in Rheumatoid Arthritis

Background: Rheumatoid arthritis (RA) is an autoimmune disease often. Emerging evidence suggests that antisense ZNFX1 RNA1 (ZFAS1) participate in physiological and pathological processes in RA. However, knowledge ZFAS1 in RA is limited, the potential paths ZFAS1 work needs to be investigated further.


Methods: Levels ZFAS1, microRNA (mir) -2682-5p, and ADAM metallopeptidase with thrombospondin type 1 motif 9 (ADAMTS9) were estimated using real-time quantitative polymerase chain reaction (qRT-PCR) assay. 3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide (MTT) assay was performed to explore the capabilities of cell proliferation in fibroblast-like synoviocytes (FLS-RA). Cell apoptosis was measured by flow cytometry. Also, the rate ADAMTS9, a protein associated with apoptosis, Cleaved-caspase-3 (active large subunit), and autophagy-related protein identified adopt western blot. Enzyme-linked immunosorbent assay (ELISA) was conducted to determine the production of inflammatory cytokines. In addition, the relationship between miR-2682-5p and ZFAS1 or ADAMTS9 verified utilize dual-luciferase reporter assay.


Results: High levels of ZFAS1 and ADAMTS9, and low levels of miR-2682-5p were observed in RA synovial tissue and FLS-RA. Knockdown of ZFAS1 cause a reduction of cell proliferation, inflammation, autophagy, and increased apoptosis in RA-FLS, while this effect was abolished by getting back in the inhibition of miR-2682-5p. In addition, miR-2682-5p effect on the phenotype of cells and the inflammatory response was eliminated by ADAMTS9 upregulation in RA-FLS. Mechanically, ZFAS1 given its role through miR-2682-5p / ADAMTS9 axis in RA.


Conclusion: ZFAS1 / miR-2682-5p / ADAMTS9 axis can modulate the behavior of cells, the inflammatory response in RA-FLS, may provide potential therapeutic targets for the treatment of RA.
Keywords: Rheumatoid arthritis; cell autophagy; inflammatory.

 Lnc RNA ZFAS1 regulates the proliferation, apoptosis, inflammatory response and autophagy of fibroblast-like synoviocytes via miR-2682-5p/ADAMTS9 axis in Rheumatoid Arthritis
Lnc RNA ZFAS1 regulates the proliferation, apoptosis, inflammatory response and autophagy of fibroblast-like synoviocytes via miR-2682-5p/ADAMTS9 axis in Rheumatoid Arthritis

Estrogen downregulates the expression of TAK1 in human fibroblast-like synoviocytes and models of rheumatoid arthritis

Transforming growth factor-β-activated kinase 1 (TAK1), a member of the protein kinase family of mitogen-activated, plays a key role in the pathogenesis and progression of rheumatoid arthritis (RA). Estrogen has been reported previously to delay the progression of arthritis. However, the exact association between TAK1 and estrogen remains elusive. This study demonstrated that TAK1 synoviocytes is upregulated in patients with RA compared to patients with osteoarthritis and healthy controls. In addition, the TAK1 also expressed in cultured fibroblast-like synoviocytes (FLS), and the levels were decreased significantly in 17β-estradiol (E2) -treated cells in a dose-dependent manner

. In addition, administration of E2 significantly decreased expression of TAK1 and attenuated the development of collagen-induced arthritis (CIA). Taken together, the findings from this study suggest that E2 mediates TAK1 decline in both FLS and the CIA, which later resulted in the suppression of pathological processes CIA. Therefore, estrogen may serve as a potential therapeutic agent for the treatment of RA by targeting TAK1.

Human CD3+ T Cells (Pan T Cells), Cryopreserved

M1299-30 each Ask for price

Human CD3+ T Cells (Pan T Cells), Cryopreserved

M1299-40 each Ask for price

Human fibroblast-like synoviocytes: Rheumatoid Arthritis (HFLS-RA)

P0004019 One Frozen vial
EUR 700

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Human fibroblast-like synoviocytes (HFLS)

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Endothelial Cryopreserve Media

FM300 10 ml
EUR 308.4

Human Synoviocyte Growth Medium

C0013-44 RT 500 mL Bottle
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CRYOPRESERVATION BAG, 50ML

91-200-88 1/pk
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Description: Flexible Containers; Bioprocess Bags and Parts

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EUR 100.8
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Cryopreservation Medium For Human Embryonic Stem Cells

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Cryopreservation Medium

TM024 100ml
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Human Fibroblast-Like Synoviocyte Normal Tissue, Adult

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Description: Human Fibroblast-Like Synoviocytes (HFLS) are isolated from normal synovial tissues. They are cryopreserved at second passage and can be cultured and propagated at least 5 population doublings.

Human Fibroblast-Like Synoviocyte Osteo Arthritis, Adult

ABC-TC3620 1 vial Ask for price
Description: Human Fibroblast-Like Synoviocytes (HFLS) are isolated from synovial tissues obtained from patients with Rheumatoid Arthritis (RA) / Osteoarthritis (OA). They are cryopreserved at second passage and can be cultured and propagated at least 5 population doubling.

Serum Free Cryopreservation Medium

TM026 25 ml
EUR 50

AddexBio Cryopreservation Medium

C0002-20mL RT vial
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AddexBio Cryopreservation Medium

C0002-01-20mL RT vial
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Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult

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Description: Human Fibroblast-Like Synoviocytes (HFLS) are isolated from synovial tissues obtained from patients with Rheumatoid Arthritis (RA) / Osteoarthritis (OA). They are cryopreserved at second passage and can be cultured and propagated at least 5 population doubling.

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COOLCELL SV2 STEMCELL CRYOPRESERVATION SYSTEM INCLUDES THE XT STARTER BENCHTOP COOLER, COOLRACK SV2 AND COOLCELL SV2 CELL FREEZING CONTAINER FOR 12 INJECTABLE VIALS

432012 1/pk
EUR 1024.8
Description: BioCision; BioCision CoolCell

COOLCELL SV10 STEMCELL CRYOPRESERVATION SYSTEM INCLUDES THE XT STARTER BENCHTOP COOLER, COOLRACK SV10 AND COOLCELL SV10 CELL FREEZING CONTAINER FOR 6 INJECTABLE VIALS

432013 1/pk
EUR 1024.8
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Human synovial apoptosis inhibitor 1, synoviolin(SYVN1) ELISA Kit

NSL2294Hu 96 wells
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Total RNA - Human Tumor Tissue: Synoviosarcoma

R1235257-10 10 ug
EUR 400

Total Protein - Human Tumor Tissue: Synoviosarcoma

P1235257 1 mg
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Human E3 ubiquitin- protein ligase synoviolin, SYVN1 ELISA KIT

ELI-29339h 96 Tests
EUR 988.8

SYVN1 (untagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2

SC101046 10 µg Ask for price

SYVN1 (untagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1

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SYVN1 (untagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1

SC324298 10 µg Ask for price

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

abx383609-96tests 96 tests
EUR 1093.2

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

AE16187HU-48Tests 48 Tests
EUR 325
Description: Human (Homo sapiens)

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

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EUR 610
Description: Human (Homo sapiens)

Human E3 ubiquitin-protein ligase synoviolin(SYVN1) Elisa Kit

EK713836 96 Wells
EUR 0.4

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

KTE60446-96T5 96 T×5
EUR 2629
Description: This Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

KTE60446-96T50 96 T×50
EUR 24569
Description: This Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.

SYVN1 (GFP-tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1

RG207132 10 µg Ask for price

SYVN1 (GFP-tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2

RG220540 10 µg Ask for price

ELISA kit for Human E3 ubiquitin-protein ligase synoviolin (SYVN1)

KTE60446-48T 48T
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Description: Quantitative sandwich ELISA for measuring Human E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human E3 ubiquitin-protein ligase synoviolin (SYVN1)

KTE60446-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Human E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human E3 ubiquitin-protein ligase synoviolin (SYVN1)

KTE60446-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

SYVN1 (Myc-DDK-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1

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SYVN1 (Myc-DDK-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2

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Human E3 ubiquitin-Protein Ligase synoviolin, SYVN1 GENLISA ELISA

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Lenti ORF clone of Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, mGFP tagged

RC220540L2 10 µg Ask for price

Lenti ORF clone of Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, mGFP tagged

RC220540L4 10 µg Ask for price

Lenti-ORF clone of SYVN1 (mGFP-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1

RC207132L4 10 µg Ask for price

Lenti ORF clone of Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, Myc-DDK-tagged

RC220540L1 10 µg Ask for price

Lenti ORF clone of Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, Myc-DDK-tagged

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Lenti-ORF clone of SYVN1 (Myc-DDK-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1

RC207132L3 10 µg Ask for price

Lenti ORF particles, SYVN1 (mGFP-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1, 200ul, >10^7 TU/mL

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Lenti ORF particles, SYVN1 (mGFP-tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, 200ul, >10^7 TU/mL

RC220540L2V 200 µl Ask for price

Lenti ORF particles, SYVN1 (mGFP-tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, 200ul, >10^7 TU/mL

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Lenti ORF particles, SYVN1 (Myc-DDK tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, 200ul, >10^7 TU/mL

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Lenti ORF particles, SYVN1 (Myc-DDK tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, 200ul, >10^7 TU/mL

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Lenti ORF particles, SYVN1 (Myc-DDK-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1, 200ul, >10^7 TU/mL

RC207132L3V 200 µl Ask for price

Synovial Apoptosis Inhibitor 1, Synoviolin Antibody

20-abx115960
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Syvn1 (untagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), (10 ug)

RN210996 10 µg Ask for price

Syvn1 (GFP-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1)

MG209408 10 µg Ask for price

Syvn1 (Myc-DDK-tagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), (10 ug)

RR210996 10 µg Ask for price

Lenti ORF clone of Syvn1 (mGFP-tagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), (10 ug)

RR210996L4 10 µg Ask for price

Lenti ORF clone of Syvn1 (Myc-DDK-tagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), (10 ug)

RR210996L3 10 µg Ask for price

Syvn1 (GFP-tagged) - Mouse synovial apoptosis inhibitor 1 synoviolin (Syvn1) transcript variant 2, (10ug)

MG219322 10 µg Ask for price

Syvn1 (untagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1, (10ug)

MC204599 10 µg Ask for price

Lenti ORF particles, Syvn1 (Myc-DDK-tagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), 200ul, >10^7 TU/mL

RR210996L3V 200 µl Ask for price

Lenti ORF particles, Syvn1 (GFP-tagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), 200ul, >10^7 TU/mL

RR210996L4V 200 µl Ask for price

E3 Ubiquitin-Protein Ligase Synoviolin (HRD1) Antibody

abx031572-400ul 400 ul
EUR 627.6

E3 Ubiquitin-Protein Ligase Synoviolin (HRD1) Antibody

abx031572-80l 80 µl
EUR 343.2

Mouse E3 ubiquitin- protein ligase synoviolin, Syvn1 ELISA KIT

ELI-23703m 96 Tests
EUR 1038

Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 2

MR219322 10 µg Ask for price

Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1

MR209408 10 µg Ask for price

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx238463-100ug 100 ug
EUR 610.8

E3 ubiquitin-protein ligase synoviolin (SYVN1) Antibody

20-abx211798
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx025097-400ul 400 ul
EUR 627.6

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx025097-80l 80 µl
EUR 343.2

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx025098-400ul 400 ul
EUR 627.6

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx025098-80l 80 µl
EUR 343.2

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx431931-200ul 200 ul
EUR 460.8

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

abx431932-200ul 200 ul
EUR 460.8

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

20-abx002034
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

20-abx302155
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human Synovial Fluid

ABC-TC3824 1 vial Ask for price
Description: Human synovial tissue and fluid are isolated from a single donor. This fluid has been frozen fresh. Synovial tissue and fluid can enable your knowledge of disease mechanisms and allows you to correlate clinical symptoms with pathology. Most importantly these observations may lead to the discovery of new therapeutic targets in arthritis disease.Development period: Postnatal

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (HRP)

20-abx314566
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

abx390695-96tests 96 tests
EUR 1093.2

Syvn1 ELISA Kit| Mouse E3 ubiquitin-protein ligase synoviolin E

EF016338 96 Tests
EUR 826.8

Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

AE16188MO-48Tests 48 Tests
EUR 325
Description: Mouse (Mus musculus)

Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

AE16188MO-96Tests 96 Tests
EUR 610
Description: Mouse (Mus musculus)

Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

KTE70316-96T5 96 T×5
EUR 2629
Description: This Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.

Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

KTE70316-96T50 96 T×50
EUR 24569
Description: This Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.

CryoProtX

M-MD1-61 46 x 1.5 ml ml
EUR 360
Description: CryoProtX

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (FITC)

20-abx314567
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

ELISA kit for Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1)

KTE70316-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1)

KTE70316-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1)

KTE70316-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Lenti ORF clone of Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 2

MR219322L3 10 µg Ask for price

Lenti ORF clone of Syvn1 (mGFP-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 2

MR219322L4 10 µg Ask for price

Lenti ORF clone of Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1

MR209408L3 10 µg Ask for price

Lenti ORF clone of Syvn1 (mGFP-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1

MR209408L4 10 µg Ask for price

3`UTR clone of synovial apoptosis inhibitor 1 synoviolin (SYVN1) transcript variant 1 for miRNA target validation

SC212618 10 µg Ask for price

3`UTR clone of synovial apoptosis inhibitor 1 synoviolin (SYVN1) transcript variant 2 for miRNA target validation

SC212619 10 µg Ask for price

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (Biotin)

20-abx314568
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Lenti ORF particles, Syvn1 (GFP-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 2, 200ul, >10^7 TU/mL

MR219322L4V 200 µl Ask for price

Lenti ORF particles, Syvn1 (GFP-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1, 200ul, >10^7 TU/mL

MR209408L4V 200 µl Ask for price

Human Synovial Stromal Cells

ABC-TC3826 1 vial Ask for price
Description: Primary Human Synovial Stromal Cells were initiated by elutriation from normal human synovial tissue.These cells were originated using Complete Serum-Free Medium Kit With AcceSup™, are available at <12 Cumulative Population Doublings (CPD) in vitro [Passage 3] and were cryopreserved in aliquots of ~1.5×10^6 cells. This vial will initiate a Passage 4 cell culture in a 75cm2 flask.

Lenti ORF particles, Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 2, 200ul, >10^7 TU/mL

MR219322L3V 200 µl Ask for price

Lenti ORF particles, Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1, 200ul, >10^7 TU/mL

MR209408L3V 200 µl Ask for price

CryoProtX Eco Screen

M-MD1-61-ECO 46 x 1.5 ml ml
EUR 360
Description: CryoProtX Eco Screen

CryoProtX Mix Reagents 1.5 mL

M-MDSR-61 1.5 ml ml
EUR 37
Description: CryoProtX Mix Reagents 1.5 mL

Single Donor Human Synovial Fluid

IRHUSYNS1ML each
EUR 427
Description: Single Donor Human Synovial Fluid

CryoProtX Mix Eco Reagents 1.5 mL

M-MDSR-61-ECO 1.5 ml ml
EUR 37
Description: CryoProtX Mix Eco Reagents 1.5 mL

Nori® Human IL-12 ELISA Kit- Synovial Fluid

GR106141-SF 96-well
EUR 461

Human Synovial Tissue Frozen Tissue Block

ABC-TC3827 1 vial Ask for price
Description: Human synovial tissue embedded in OCT is isolated from a single donor. This tissue has been isolated and quickly frozen in OCT blocks using isopentane. Synovial tissue can enable your knowledge of disease mechanisms and allows you to correlate clinical symptoms with pathology. Most importantly these observations may lead to the discovery of new therapeutic targets in arthritis disease. This tissue has been isolated from a normal donor.Development period: Postnatal

Human Synovial Tissue Parrafin Embedded

ABC-TC3828 1 vial Ask for price
Description: Human synovial tissue and fluid are isolated from a single donor. These tissues have been fixed and embedded in paraffin. Synovial tissue and fluid can enable your knowledge of disease mechanisms and allows you to correlate clinical symptoms with pathology. Most importantly these observations may lead to the discovery of new therapeutic targets in arthritis disease. These tissues have been isolated from a normal donorDevelopment period: Postnatal

FD Tissue Cryoprotection Solution™

PC102 250 ml
EUR 156

Human Bone Joint PrimaCell: Normal Synovial Cell

2-96011 1 Kit Ask for price

Nori® Human VEGF ELISA Kit- Synovial Fluid-2 Plates

GR111005-SF-2 2 x 96-well
EUR 832

Nori® Human IL-13 ELISA Kit- Synovial Fluid-2 Plates

GR111006-SF-2 2 x 96-well
EUR 832

Human Synovial Microvascular Endothelial Cells

HEC10 500,000+ Cells
EUR 1296

Human Synovial Microvascular Endothelial Cells

ABC-TC3825 1 vial Ask for price
Description: Human Synovial Microvascular Endothelial Cell were initiated by elutriation from dispase dissociated normal human synovial tissue .These cells were originated using Complete Serum-Free Medium Kit With AcceSup™, are available at <12 Cumulative Population Doublings (CPD) in vitro [Passage 3] and were cryopreserved in aliquots of ~1.5×10^6 cells. This vial will initiate a Passage 4 cell culture in a 75cm2 flask.

Human Primary Osteoarthritis Synovial Fibroblasts

T5408 5 x 10^5/ 1.0 ml Ask for price

SSX1 (untagged)-Human synovial sarcoma, X breakpoint 1 (SSX1)

SC122725 10 µg Ask for price

SSX7 (untagged)-Human synovial sarcoma, X breakpoint 7 (SSX7)

SC306814 10 µg Ask for price

Paraffin Tissue Section - Human Bone Tumor: Synovial Sarcoma

T2235023-8 5 slides
EUR 238

SSX7 (GFP-tagged) - Human synovial sarcoma, X breakpoint 7 (SSX7)

RG213920 10 µg Ask for price

SSX1 (GFP-tagged) - Human synovial sarcoma, X breakpoint 1 (SSX1)

RG201600 10 µg Ask for price

SSX2B (untagged)-Human synovial sarcoma X breakpoint 2B (SSX2B)

SC327386 10 µg Ask for price

Human Primary Rheumatoid Arthritis Synovial Fibroblasts

T5409 5 x 10^5 / 1.0 ml
EUR 1595

SSX2B (GFP-tagged) - Human synovial sarcoma, X breakpoint 2B (SSX2B)

RG228751 10 µg Ask for price

Human Bone Joint PrimaCell: Normal Synovial Cells Growth Medium

9-46011 5 x 100 ml Ask for price

SSX1 (Myc-DDK-tagged)-Human synovial sarcoma, X breakpoint 1 (SSX1)

RC201600 10 µg Ask for price

SSX7 (Myc-DDK-tagged)-Human synovial sarcoma, X breakpoint 7 (SSX7)

RC213920 10 µg Ask for price

Human Bone Joint Tissue Preparation Buffer: Normal Synovial Cells

9-80011 1 x 100 ml Ask for price

SSX1 Synovial Sarcoma, X Breakpoint 1 Human Recombinant Protein

PROTQ16384 Regular: 10ug
EUR 380.4
Description: SSX1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 211 amino acids (1-188 a.a) and having a molecular mass of 24.3kDa.;SSX1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

SSX2 Synovial Sarcoma, X Breakpoint 2 Human Recombinant Protein

PROTQ16385 Regular: 10ug
EUR 380.4
Description: SSX2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 210 amino acids (1-188a.a) and having a molecular mass of 24.0kDa. ;SSX2 is fused to a 22 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

SSX2B (Myc-DDK-tagged)-Human synovial sarcoma, X breakpoint 2B (SSX2B)

RC228751 10 µg Ask for price

Lenti ORF clone of Human synovial sarcoma, X breakpoint 1 (SSX1), mGFP tagged

RC201600L2 10 µg Ask for price

Lenti ORF clone of Human synovial sarcoma, X breakpoint 1 (SSX1), mGFP tagged

RC201600L4 10 µg Ask for price

Lenti ORF clone of Human synovial sarcoma, X breakpoint 7 (SSX7), mGFP tagged

RC213920L4 10 µg Ask for price

Lenti ORF clone of Human synovial sarcoma, X breakpoint 2B (SSX2B), mGFP tagged

RC228751L4 10 µg Ask for price

Lenti ORF clone of Human synovial sarcoma, X breakpoint 1 (SSX1), Myc-DDK-tagged

RC201600L1 10 µg Ask for price

Lenti ORF clone of Human synovial sarcoma, X breakpoint 1 (SSX1), Myc-DDK-tagged

RC201600L3 10 µg Ask for price

Lenti ORF clone of Human synovial sarcoma, X breakpoint 7 (SSX7), Myc-DDK-tagged

RC213920L3 10 µg Ask for price

Lenti ORF clone of Human synovial sarcoma, X breakpoint 2B (SSX2B), Myc-DDK-tagged

RC228751L3 10 µg Ask for price

SSX3 (untagged)-Human synovial sarcoma, X breakpoint 3 (SSX3), transcript variant 2

SC125740 10 µg Ask for price

SSX2 (untagged)-Human synovial sarcoma, X breakpoint 2 (SSX2), transcript variant 1

SC126184 10 µg Ask for price

SSX4 (untagged)-Human synovial sarcoma, X breakpoint 4 (SSX4), transcript variant 1

SC126384 10 µg Ask for price

SSX5 (untagged)-Human synovial sarcoma, X breakpoint 5 (SSX5), transcript variant 1

SC122901 10 µg Ask for price

SSX5 (untagged)-Human synovial sarcoma, X breakpoint 5 (SSX5), transcript variant 2

SC123342 10 µg Ask for price

SSX2 (untagged)-Human synovial sarcoma, X breakpoint 2 (SSX2), transcript variant 2

SC319207 10 µg Ask for price

SSX3 (untagged)-Human synovial sarcoma, X breakpoint 3 (SSX3), transcript variant 1

SC304892 10 µg Ask for price

SSX4 (untagged)-Human synovial sarcoma, X breakpoint 4 (SSX4), transcript variant 2

SC307019 10 µg Ask for price

SSX1 (untagged) - Human synovial sarcoma, X breakpoint 1 (SSX1), transcript variant 1

SC334298 10 µg Ask for price

SSX2 (untagged) - Human synovial sarcoma, X breakpoint 2 (SSX2), transcript variant 3

SC334515 10 µg Ask for price

SSX4B (untagged)-Human synovial sarcoma, X breakpoint 4B (SSX4B), transcript variant 1

SC302796 10 µg Ask for price

SSX4B (untagged)-Human synovial sarcoma, X breakpoint 4B (SSX4B), transcript variant 2

SC311197 10 µg Ask for price

SSX2B (untagged) - Human synovial sarcoma, X breakpoint 2B (SSX2B), transcript variant 3

SC334523 10 µg Ask for price

SSX2B (untagged) - Human synovial sarcoma, X breakpoint 2B (SSX2B), transcript variant 1

SC334593 10 µg Ask for price

SSX5 (GFP-tagged) - Human synovial sarcoma, X breakpoint 5 (SSX5), transcript variant 2

RG216184 10 µg Ask for price

SSX3 (GFP-tagged) - Human synovial sarcoma, X breakpoint 3 (SSX3), transcript variant 2

RG203244 10 µg Ask for price

SSX2 (GFP-tagged) - Human synovial sarcoma, X breakpoint 2 (SSX2), transcript variant 2

RG203504 10 µg Ask for price

SSX2 (GFP-tagged) - Human synovial sarcoma, X breakpoint 2 (SSX2), transcript variant 1

RG201214 10 µg Ask for price

SSX5 (GFP-tagged) - Human synovial sarcoma, X breakpoint 5 (SSX5), transcript variant 1

RG202208 10 µg Ask for price


Since this article has been alleged infringement and corresponding study author did not respond to our request to prove the authenticity of the data and figures, “Mir-20a Regulates fibroblast-like synoviocyte proliferation and apoptosis in rheumatoid arthritis, by X.-J. Wei, X.- W. Li, J.-L. Lu, long Z.-X., J.-Q. Liang, S.-B. Wei, C.-X. Lu, Lu W.-Z., published in Eur Rev Med Pharmacol Sci 2017; 21 (17): 3886-3893-PMID: 28,975,975 “has been withdrawn. Publisher apologizes for any inconvenience this may cause.