Lnc RNA ZFAS1 regulates the proliferation, apoptosis, inflammatory response and autophagy of fibroblast-like synoviocytes via miR-2682-5p/ADAMTS9 axis in Rheumatoid Arthritis

Background: Rheumatoid arthritis (RA) is an autoimmune disease often. Emerging evidence suggests that antisense ZNFX1 RNA1 (ZFAS1) participate in physiological and pathological processes in RA. However, knowledge ZFAS1 in RA is limited, the potential paths ZFAS1 work needs to be investigated further.


Methods: Levels ZFAS1, microRNA (mir) -2682-5p, and ADAM metallopeptidase with thrombospondin type 1 motif 9 (ADAMTS9) were estimated using real-time quantitative polymerase chain reaction (qRT-PCR) assay. 3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide (MTT) assay was performed to explore the capabilities of cell proliferation in fibroblast-like synoviocytes (FLS-RA). Cell apoptosis was measured by flow cytometry. Also, the rate ADAMTS9, a protein associated with apoptosis, Cleaved-caspase-3 (active large subunit), and autophagy-related protein identified adopt western blot. Enzyme-linked immunosorbent assay (ELISA) was conducted to determine the production of inflammatory cytokines. In addition, the relationship between miR-2682-5p and ZFAS1 or ADAMTS9 verified utilize dual-luciferase reporter assay.


Results: High levels of ZFAS1 and ADAMTS9, and low levels of miR-2682-5p were observed in RA synovial tissue and FLS-RA. Knockdown of ZFAS1 cause a reduction of cell proliferation, inflammation, autophagy, and increased apoptosis in RA-FLS, while this effect was abolished by getting back in the inhibition of miR-2682-5p. In addition, miR-2682-5p effect on the phenotype of cells and the inflammatory response was eliminated by ADAMTS9 upregulation in RA-FLS. Mechanically, ZFAS1 given its role through miR-2682-5p / ADAMTS9 axis in RA.


Conclusion: ZFAS1 / miR-2682-5p / ADAMTS9 axis can modulate the behavior of cells, the inflammatory response in RA-FLS, may provide potential therapeutic targets for the treatment of RA.
Keywords: Rheumatoid arthritis; cell autophagy; inflammatory.

 Lnc RNA ZFAS1 regulates the proliferation, apoptosis, inflammatory response and autophagy of fibroblast-like synoviocytes via miR-2682-5p/ADAMTS9 axis in Rheumatoid Arthritis
Lnc RNA ZFAS1 regulates the proliferation, apoptosis, inflammatory response and autophagy of fibroblast-like synoviocytes via miR-2682-5p/ADAMTS9 axis in Rheumatoid Arthritis

Estrogen downregulates the expression of TAK1 in human fibroblast-like synoviocytes and models of rheumatoid arthritis

Transforming growth factor-β-activated kinase 1 (TAK1), a member of the protein kinase family of mitogen-activated, plays a key role in the pathogenesis and progression of rheumatoid arthritis (RA). Estrogen has been reported previously to delay the progression of arthritis. However, the exact association between TAK1 and estrogen remains elusive. This study demonstrated that TAK1 synoviocytes is upregulated in patients with RA compared to patients with osteoarthritis and healthy controls. In addition, the TAK1 also expressed in cultured fibroblast-like synoviocytes (FLS), and the levels were decreased significantly in 17β-estradiol (E2) -treated cells in a dose-dependent manner

. In addition, administration of E2 significantly decreased expression of TAK1 and attenuated the development of collagen-induced arthritis (CIA). Taken together, the findings from this study suggest that E2 mediates TAK1 decline in both FLS and the CIA, which later resulted in the suppression of pathological processes CIA. Therefore, estrogen may serve as a potential therapeutic agent for the treatment of RA by targeting TAK1.

CG8889-RA Antibody

CSB-PA227598-100ul 100ul
EUR 316
Description: A polyclonal antibody against CG8889-RA. Recognizes CG8889-RA from Drosophila melanogaster. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

AQ-RA 741

B7003-10 10 mg
EUR 302
Description: AQ-RA 741 is a potent and selective M2 antagonist, with high affinity for cardiac M2 sites (pKi = 8.30) [1].The M2 muscarinic receptor subtype is involved in the regulation of heart rate, mediating muscarinic receptor-dependent movement, antinociceptive responses and temperature control [2].

AQ-RA 741

B7003-50 50 mg
EUR 1114
Description: AQ-RA 741 is a potent and selective M2 antagonist, with high affinity for cardiac M2 sites (pKi = 8.30) [1].The M2 muscarinic receptor subtype is involved in the regulation of heart rate, mediating muscarinic receptor-dependent movement, antinociceptive responses and temperature control [2].

RA-X Ⅵ

TBZ0772 unit Ask for price

IL-1 RA, human recombinant

4263-100
EUR 262

IL-1 RA, human recombinant

4263-1000
EUR 1246

IL-1 RA, human recombinant

4263-20
EUR 142

Anti-RA alpha antibody

STJ95372 200 µl
EUR 197
Description: Rabbit polyclonal to RARalpha.

Anti-RA beta antibody

STJ95373 200 µl
EUR 197
Description: Rabbit polyclonal to RARbeta.

CXCR1/IL-8 RA

MO15072 500 ug
EUR 910

Human Bone Marrow CD34+ Stem Cells, Cryopreserved

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IL-1 RA, murine recombinant

4264-10
EUR 164

IL-1 RA, murine recombinant

4264-1000
EUR 4220

IL-1 RA, murine recombinant

4264-50
EUR 370

IL-31 RA Recombinant Protein

11-125 0.1 mg
EUR 595.25
Description: Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex.

IL-31 RA Recombinant Protein

11-354 0.1 mg
EUR 595.25
Description: Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex.

Human Retinoic acid/ Tretinoin,RA ELISA Kit

ELA-E2553h 96 Tests
EUR 824

Human Cord Blood CD34+ Cells, Cryopreserved, single donor

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M1299-10 Ask for price

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M1299-30 Ask for price

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M1299-40 Ask for price

CXCR1/IL-8 RA-Fluorescein Labeled

FC15001 100 Tests
EUR 448

Anti-Phospho-RA alpha (S77) antibody

STJ90963 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-RARalpha (S77).

anti-CD45 RA IgG2 monoclonal antibody

067-A-01mg 0,1 mg
EUR 267.5
Description: anti-CD45 RA IgG2 monoclonal antibody

anti-CD45 RA IgG2 monoclonal antibody

067-A-1000ug 1000 ug
EUR 1282.5
Description: anti-CD45 RA IgG2 monoclonal antibody

Human  Peripheral  Blood  CD14+ Monocytes, Cryopreserved / Untouched

PBCD14U-C10M - Ask for price

Human IL-17 RA Protein (Leu 33-Trp 320) [Fc]

VAng-1780Lsx-1mg 1 mg
EUR 2745
Description: Human IL-17 RA (CD217), Fc tag, is expressed in human 293 cells. (Uniprot ID: NP_055154.3)

Human IL-17 RA Protein (Leu 33-Trp 320) [Fc]

VAng-1780Lsx-200g 200 µg
EUR 765
Description: Human IL-17 RA (CD217), Fc tag, is expressed in human 293 cells. (Uniprot ID: NP_055154.3)

Human IL-17 RA Protein (Leu 33-Trp 320) [His]

VAng-1781Lsx-100g 100 µg
EUR 820
Description: Human IL-17 RA (CD217), His tag, is expressed in human 293 cells. (Uniprot ID: NP_055154.3)

Human IL-17 RA Protein (Leu 33-Trp 320) [His]

VAng-1781Lsx-1mg 1 mg
EUR 4449
Description: Human IL-17 RA (CD217), His tag, is expressed in human 293 cells. (Uniprot ID: NP_055154.3)

Human IL-27 Ra Protein (Gln 33-Arg 514) [Fc]

VAng-1817Lsx-100g 100 µg
EUR 738
Description: Human IL-27 Ra, Fc tag, Human protein expressed in human 293 cells. (Uniprot ID: AAH28003)

Human IL-27 Ra Protein (Gln 33-Arg 514) [Fc]

VAng-1817Lsx-1mg 1 mg
EUR 4174
Description: Human IL-27 Ra, Fc tag, Human protein expressed in human 293 cells. (Uniprot ID: AAH28003)

Human IL-31 RA Protein (Ala 20-Glu 519) [Fc]

VAng-1821Lsx-100g 100 µg
EUR 1013
Description: Human IL-31 RA, Fc tag, Human protein expressed in human 293 cells. (Uniprot ID: Q8NI17-1)

Human IL-31 RA Protein (Ala 20-Glu 519) [Fc]

VAng-1821Lsx-1mg 1 mg
EUR 6402
Description: Human IL-31 RA, Fc tag, Human protein expressed in human 293 cells. (Uniprot ID: Q8NI17-1)

Recombinant Human IL-27 Ra/WSX-1/TCCR (C-Fc)

C615-10ug 10ug
EUR 141
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human IL-27 Ra/WSX-1/TCCR (C-Fc)

C615-1mg 1mg
EUR 1420
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human IL-27 Ra/WSX-1/TCCR (C-Fc)

C615-500ug 500ug
EUR 1328
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human IL-27 Ra/WSX-1/TCCR (C-Fc)

C615-50ug 50ug
EUR 303
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Positively Selected Normal Peripheral Blood CD19+ B Cells, Cryopreserved

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Biotinylated Human IL-17 RA Protein (Leu 33-Trp 320) [Fc]

VAng-1614Lsx-200g 200 µg
EUR 3844
Description: Biotinylated Human IL-17 RA (CD217), Fc tag, is expressed in human 293 cells. (Uniprot ID: NP_055154.3)

Biotinylated Human IL-17 RA Protein (Leu 33-Trp 320) [Fc]

VAng-1614Lsx-25g 25 µg
EUR 1013
Description: Biotinylated Human IL-17 RA (CD217), Fc tag, is expressed in human 293 cells. (Uniprot ID: NP_055154.3)

Biotinylated Human IL-17 RA Protein (Leu 33-Trp 320) [His]

VAng-1615Lsx-200g 200 µg
EUR 3844
Description: Biotinylated Human IL-17 RA (CD217), His tag, is expressed in human 293 cells. (Uniprot ID: Q96F46-1)

Biotinylated Human IL-17 RA Protein (Leu 33-Trp 320) [His]

VAng-1615Lsx-25g 25 µg
EUR 1013
Description: Biotinylated Human IL-17 RA (CD217), His tag, is expressed in human 293 cells. (Uniprot ID: Q96F46-1)

anti-CD45 RA B-cells, T-cells, NK-cells

516-A-01mg 0,1 mg
EUR 267.5
Description: anti-CD45 RA B-cells, T-cells, NK-cells

anti-CD45 RA B-cells, T-cells, NK-cells

516-A-1000ug 1000 ug
EUR 1282.5
Description: anti-CD45 RA B-cells, T-cells, NK-cells

Rfng ELISA Kit| Rat Beta-1,3-N-acetylglucosaminyltransferase ra

EF019267 96 Tests
EUR 689

Human  Peripheral  Blood  CD4+  T  Lymphocytes, Cryopreserved

PBCD4-C10M - Ask for price

Rat Tumor necrosis factor Receptor alpha(TNF-Ra) ELISA Kit

QY-E11745 96T
EUR 374

Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1)ELISA kit

CSB-E17965h-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1)ELISA kit

1-CSB-E17965h
  • EUR 703.00
  • EUR 4843.00
  • EUR 2570.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rheumatoid Arthritis Exosome

P141-RA - Ask for price

Rheumatoid Arthritis Exosome RNA

P241-RA - Ask for price

0.1 G GENTAMICIN SULFATE, POWDER

61-098-RA 0,1 g/pk
EUR 62
Description: Media Catalog; Cell Culture Reagents

0.1 G PUROMYCIN DIHYDROCHLORIDE, POWDER

61-385-RA 0,1 g/pk
EUR 163
Description: Media Catalog; Cell Culture Reagents

Heating Element

B1000-RA-E 1 PC
EUR 1151.63

Rat Collagen Type IV Alpha 1 (COL4a1) ELISA Kit

DLR-COL4a1-Ra-48T 48T
EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Rat Collagen Type IV Alpha 1 (COL4a1) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Collagen Type IV Alpha 1 (COL4a1) ELISA Kit

DLR-COL4a1-Ra-96T 96T
EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Rat Collagen Type IV Alpha 1 (COL4a1) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Collagen Type VI Alpha 1 (COL6a1) ELISA Kit

DLR-COL6a1-Ra-48T 48T
EUR 549
Description: A sandwich quantitative ELISA assay kit for detection of Rat Collagen Type VI Alpha 1 (COL6a1) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Collagen Type VI Alpha 1 (COL6a1) ELISA Kit

DLR-COL6a1-Ra-96T 96T
EUR 718
Description: A sandwich quantitative ELISA assay kit for detection of Rat Collagen Type VI Alpha 1 (COL6a1) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Collagen Type IX Alpha 1 (COL9a1) ELISA Kit

DLR-COL9a1-Ra-48T 48T
EUR 549
Description: A sandwich quantitative ELISA assay kit for detection of Rat Collagen Type IX Alpha 1 (COL9a1) in samples from tissue homogenates or other biological fluids.

Rat Collagen Type IX Alpha 1 (COL9a1) ELISA Kit

DLR-COL9a1-Ra-96T 96T
EUR 718
Description: A sandwich quantitative ELISA assay kit for detection of Rat Collagen Type IX Alpha 1 (COL9a1) in samples from tissue homogenates or other biological fluids.

Rat Cartilage Oligomeric Matrix Protein (COMP) ELISA Kit

DLR-COMP-Ra-48T 48T
EUR 528
Description: A sandwich quantitative ELISA assay kit for detection of Rat Cartilage Oligomeric Matrix Protein (COMP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Cartilage Oligomeric Matrix Protein (COMP) ELISA Kit

DLR-COMP-Ra-96T 96T
EUR 690
Description: A sandwich quantitative ELISA assay kit for detection of Rat Cartilage Oligomeric Matrix Protein (COMP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Catechol-O-Methyltransferase (COMT) ELISA Kit

DLR-COMT-Ra-48T 48T
EUR 549
Description: A sandwich quantitative ELISA assay kit for detection of Rat Catechol-O-Methyltransferase (COMT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Catechol-O-Methyltransferase (COMT) ELISA Kit

DLR-COMT-Ra-96T 96T
EUR 718
Description: A sandwich quantitative ELISA assay kit for detection of Rat Catechol-O-Methyltransferase (COMT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Coronin 1A (CORO1A) ELISA Kit

DLR-CORO1A-Ra-48T 48T
EUR 549
Description: A sandwich quantitative ELISA assay kit for detection of Rat Coronin 1A (CORO1A) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Coronin 1A (CORO1A) ELISA Kit

DLR-CORO1A-Ra-96T 96T
EUR 718
Description: A sandwich quantitative ELISA assay kit for detection of Rat Coronin 1A (CORO1A) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Ceruloplasmin (CP) ELISA Kit

DLR-CP-Ra-48T 48T
EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Rat Ceruloplasmin (CP) in samples from serum, plasma or other biological fluids.

Rat Ceruloplasmin (CP) ELISA Kit

DLR-CP-Ra-96T 96T
EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Rat Ceruloplasmin (CP) in samples from serum, plasma or other biological fluids.

Rat Carboxypeptidase A1, Pancreatic (CPA1) ELISA Kit

DLR-CPA1-Ra-48T 48T
EUR 549
Description: A sandwich quantitative ELISA assay kit for detection of Rat Carboxypeptidase A1, Pancreatic (CPA1) in samples from serum, plasma or other biological fluids.

Rat Carboxypeptidase A1, Pancreatic (CPA1) ELISA Kit

DLR-CPA1-Ra-96T 96T
EUR 718
Description: A sandwich quantitative ELISA assay kit for detection of Rat Carboxypeptidase A1, Pancreatic (CPA1) in samples from serum, plasma or other biological fluids.

Rat Carboxypeptidase A2, Pancreatic (CPA2) ELISA Kit

DLR-CPA2-Ra-48T 48T
EUR 549
Description: A sandwich quantitative ELISA assay kit for detection of Rat Carboxypeptidase A2, Pancreatic (CPA2) in samples from serum, plasma or other biological fluids.

Rat Carboxypeptidase A2, Pancreatic (CPA2) ELISA Kit

DLR-CPA2-Ra-96T 96T
EUR 718
Description: A sandwich quantitative ELISA assay kit for detection of Rat Carboxypeptidase A2, Pancreatic (CPA2) in samples from serum, plasma or other biological fluids.

Rat Carboxypeptidase A3, Mast Cell (CPA3) ELISA Kit

DLR-CPA3-Ra-48T 48T
EUR 549
Description: A sandwich quantitative ELISA assay kit for detection of Rat Carboxypeptidase A3, Mast Cell (CPA3) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Rat Carboxypeptidase A3, Mast Cell (CPA3) ELISA Kit

DLR-CPA3-Ra-96T 96T
EUR 718
Description: A sandwich quantitative ELISA assay kit for detection of Rat Carboxypeptidase A3, Mast Cell (CPA3) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Rat Carboxypeptidase B1, Tissue (CPB1) ELISA Kit

DLR-CPB1-Ra-48T 48T
EUR 549
Description: A sandwich quantitative ELISA assay kit for detection of Rat Carboxypeptidase B1, Tissue (CPB1) in samples from serum, plasma or other biological fluids.

Rat Carboxypeptidase B1, Tissue (CPB1) ELISA Kit

DLR-CPB1-Ra-96T 96T
EUR 718
Description: A sandwich quantitative ELISA assay kit for detection of Rat Carboxypeptidase B1, Tissue (CPB1) in samples from serum, plasma or other biological fluids.

Rat Copeptin (CPP) ELISA Kit

DLR-CPP-Ra-48T 48T
EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Rat Copeptin (CPP) in samples from serum, plasma or other biological fluids.

Rat Copeptin (CPP) ELISA Kit

DLR-CPP-Ra-96T 96T
EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Rat Copeptin (CPP) in samples from serum, plasma or other biological fluids.

Rat Cytochrome P450 Reductase (CPR) ELISA Kit

DLR-CPR-Ra-48T 48T
EUR 549
Description: A sandwich quantitative ELISA assay kit for detection of Rat Cytochrome P450 Reductase (CPR) in samples from serum, plasma or other biological fluids.

Rat Cytochrome P450 Reductase (CPR) ELISA Kit

DLR-CPR-Ra-96T 96T
EUR 718
Description: A sandwich quantitative ELISA assay kit for detection of Rat Cytochrome P450 Reductase (CPR) in samples from serum, plasma or other biological fluids.


Since this article has been alleged infringement and corresponding study author did not respond to our request to prove the authenticity of the data and figures, “Mir-20a Regulates fibroblast-like synoviocyte proliferation and apoptosis in rheumatoid arthritis, by X.-J. Wei, X.- W. Li, J.-L. Lu, long Z.-X., J.-Q. Liang, S.-B. Wei, C.-X. Lu, Lu W.-Z., published in Eur Rev Med Pharmacol Sci 2017; 21 (17): 3886-3893-PMID: 28,975,975 “has been withdrawn. Publisher apologizes for any inconvenience this may cause.