The expression of viral vectors in HEK 293 cells is a widely used procedure to obtain sufficient quantities of the desired virus. The manufacturing and purification process of these products leaves
Improvement of in situ Follicular Activation and Early Development in Cryopreserved Human Ovarian Cortical Tissue by Co-Culturing with Mesenchymal Stem Cells.
Follicle losses and network degeneration are major challenges in the ovarian tissue culture system. Mesenchymal (MSC) stem cells emit the cocktail of growth and cytokines that support adjacent cells
Cryopreserved human oocytes and cord blood cells can produce macar stem cells somatic blood cells parent cells with hla homozygous type
Human pluripotent stem cells (PSC) through somatic cell nuclear transfer (SCNT) may be an important source for regenerative treatment. Low derivation efficiency of stem cells and human oocyte
MiR-1193 represses the proliferation and induces the apoptosis of interleukin-1β-treated fibroblast-like synoviocytes via targeting JAK3
Objective: To explore the role of miR-1193 / Janus kinase 3 (JAK3) axis and the potential mechanisms in rheumatoid arthritis (RA).Methods: The dysregulated genes and microRNAs (miRNAs) are filtered
Sonic Hedgehog Regulates Proliferation, Migration and Invasion of Synoviocytes in Rheumatoid Arthritis via JNK Signaling
Enabled fibroblast-like synoviocytes (FLSs) plays a central role in synovial pannus formation and joint destruction in rheumatoid arthritis (RA). FLSs targeting could be a potential therapeutic
MicroRNA-495 attenuates proliferation and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through attenuating β-catenin pathway
Fibroblast like synoviocytes (FLSs) exert important effects in the occurrence and progression of rheumatoid arthritis (RA). MicroRNA-495 (miR-495) can regulate growth behavior of many cell types.
miR-17-5p reduces inflammation and bone erosions in collagen induced arthritis mice and directly targets the JAK-STAT pathway in rheumatoid arthritis fibroblast-like synoviocytes
Objective: Our objective was to study miR expression in rheumatoid arthritis (RA) phenotype, along with the effects and mechanism of action of miR-17-5p. Methods: An array mir done in synovial tissue
Inhibitory Effect of Tetramerized Single-Chain Variable Fragment of Anti-Cyclic Citrullinated Peptide Antibodies on the Proliferation, Activation, and Secretion of Cytokines of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis In Vitro Co-Culture System
Tetramerized single chain variable fragment (scFv) anti-cyclic citrullinated peptide (TeAb-CCP) is built tetramerized scFv anti-cyclic peptide citrullinated (CCP) antibody to p53 domain tetrameric,