MicroRNA-495 attenuates proliferation and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through attenuating β-catenin pathway

MicroRNA-495 attenuates proliferation and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through attenuating β-catenin pathway

Fibroblast like synoviocytes (FLSs) exert important effects in the occurrence and progression of rheumatoid arthritis (RA). MicroRNA-495 (miR-495) can regulate growth behavior of many cell types. Nevertheless, the role of miR-495 is still unclear in RA-FLS. We aim to explore the role and molecular mechanism of miR-495 in RA. The FLSs and synovial tissue from normal and RA cases were used in this study. RT-PCR analysis was used to test the expression of miR-495. Western blot assay was performed to determine the levels of matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-2 (MMP-2) and β-catenin.

Cell counting kit-8 (CCK-8) tests were performed to determine the proliferation of RA-FLS in the different treatment groups. The results showed that miR-495 down-regulated in the synovial tissue and RA-RA-FLSs. Overexpression of miR-495 can inhibit RA-FLS proliferation and inflammatory factor interleukin (IL) -6, IL-11 and tumor necrosis factor alpha (TNF-α), and the lower the protein expression of MMP-9 and MMP-2. In addition, miR-495 could negatively regulates the expression of β-catenin in RA-FLSs.

We also confirmed that the role of inhibition of miR-495 in RA-FLS is through the regulation of β-catenin expression. Taken together, miR-495 is downregulated in RA-FLS and RA synovial tissue, and miR-495 inhibits proliferation and the inflammatory response in RA-FLS, partly through regulating the expression of β-catenin. The miR-495 / β-catenin signaling pathway may serve as a new therapeutic target for RA.
mir-483-3p was upregulated in RA, which is explicitly promoted cell proliferation, induction of the transition phase G0 / G1-to-S, and suppressed apoptosis in RA FLSs, whereas silencing of miR-483-3p produce the opposite result.

In addition, insulin growth factor 1 (IGF-1) is detected as a direct target of miR-483-3p. IGF-1 silencing partially restored cell proliferation, the transition phase G0 / G1-to-S, and suppression of apoptosis in RA FLSs through inhibition of miR-483-3p. Our results show that miR-483-3p RA FLSs promote proliferation by targeting the IGF-1, indicating a potential strategy for diagnostic and treatment strategies for RA.

 MicroRNA-495 attenuates proliferation and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through attenuating β-catenin pathway
MicroRNA-495 attenuates proliferation and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through attenuating β-catenin pathway

MicroRNA-15a / 16 / SOX5 axis promotes migration, invasion and the inflammatory response in rheumatoid arthritis fibroblast like synoviocytes

Fibroblast like synoviocytes (FLSs) is a key effector cells in the pathogenesis of rheumatoid arthritis (RA) and featuring aggressive tumor phenotype is unique with exceptional hyperplasia, increased cell migration and invasion. How FLSs experiencing this change in RA remains unknown. We previously reported a novel function of transcription factors in RA SOX5-FLSs that promote cell migration and invasion.

In this study, we found that miR-15a / 16 directly target and suppress the expression of the 3’UTR SOX5 SOX5. In addition, miR-15a / 16 was significantly down-regulated in RA-FLSs, which is negatively correlated with the expression SOX5. Transfection with miR-15a / 16 mimic the RA-FLSs cell migration inhibiting, invasion, IL-1β and TNF expression. SOX5 expression in RA-FLSs decreased miR-15a / 16 expression and rescue miR-15a / 16-mediated inhibitory effect.

Human Bone Marrow CD34+ Stem Cells, Cryopreserved

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COOLCELL SV2 STEMCELL CRYOPRESERVATION SYSTEM INCLUDES THE XT STARTER BENCHTOP COOLER, COOLRACK SV2 AND COOLCELL SV2 CELL FREEZING CONTAINER FOR 12 INJECTABLE VIALS

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Human E3 ubiquitin- protein ligase synoviolin, SYVN1 ELISA KIT

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Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

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Synovial Apoptosis Inhibitor 1, Synoviolin Antibody

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E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

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E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (HRP)

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Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit

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Syvn1 ELISA Kit| Mouse E3 ubiquitin-protein ligase synoviolin E

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ELISA kit for Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1)

KTE70316-48T 48T
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Description: Quantitative sandwich ELISA for measuring Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1)

KTE70316-5platesof96wells 5 plates of 96 wells
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Description: Quantitative sandwich ELISA for measuring Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1)

KTE70316-96T 96T
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Description: Quantitative sandwich ELISA for measuring Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (Biotin)

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Nori® Human IL-12 ELISA Kit- Synovial Fluid

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Human Bone Joint PrimaCell: Normal Synovial Cell

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Nori® Human IL-13 ELISA Kit- Synovial Fluid-2 Plates

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Paraffin Tissue Section - Human Bone Tumor: Synovial Sarcoma

T2235023-8 5 slides
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Human Bone Joint PrimaCell: Normal Synovial Cells Growth Medium

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Human Bone Joint Tissue Preparation Buffer: Normal Synovial Cells

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SSX1 Synovial Sarcoma, X Breakpoint 1 Human Recombinant Protein

PROTQ16384 Regular: 10ug
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Description: SSX1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 211 amino acids (1-188 a.a) and having a molecular mass of 24.3kDa.;SSX1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

SSX2 Synovial Sarcoma, X Breakpoint 2 Human Recombinant Protein

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Mycoplasma synoviae PCR kit

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Human Bone Joint PrimaCell: Normal Synovial Cells Growth Supplements with Serum (for 500 ml medium)

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Synovial sarcoma tissue array

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Mycoplasma synoviae One-Step PCR kit

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Nori® Canine (dog) IL-6 ELISA Kit- Synovial Fluid

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TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

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EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF594 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC942051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF594 conjugate, Concentration: 0.1mg/mL

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BNC942062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF594 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC942062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF594 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC942085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF594 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC942085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF594 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC802051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF680 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC802051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF680 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC802062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF680 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC802062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF680 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC802085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF680 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC802085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF680 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC702051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF770 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC702051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF770 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC702062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF770 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC702062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF770 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC702085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF770 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC702085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF770 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC882051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF488A conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC882051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF488A conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC882062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF488A conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC882062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF488A conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC882085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF488A conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC882085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF488A conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC812051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF680R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC812051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF680R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC812062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF680R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC812062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF680R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC812085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF680R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC812085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF680R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC052051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF405M conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC052051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF405M conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC052062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF405M conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC052062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF405M conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC052085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF405M conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC052085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF405M conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC042051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF405S conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC042051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF405S conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC042062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF405S conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC042062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF405S conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC042085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF405S conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC042085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF405S conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC402051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF640R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC402051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF640R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC402062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF640R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC402062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF640R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC402085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF640R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC402085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF640R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNCAP2051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNCAP2051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNCAP2062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNCAP2062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNCAP2085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNCAP2085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNCA2051-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), APC conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNCA2062-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), APC conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNCA2085-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), APC conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNCP2051-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), PerCP conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNCP2062-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), PerCP conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNCP2085-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), PerCP conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNCR2051-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), RPE conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNCR2062-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), RPE conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNCR2085-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), RPE conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNCH2051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNCH2051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNCH2062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNCH2062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNCH2085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNCH2085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNCB2051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), Biotin conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNCB2051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), Biotin conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNCB2062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), Biotin conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNCB2062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), Biotin conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNCB2085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), Biotin conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNCB2085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), Biotin conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNUB2051-100 100uL
EUR 316.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), Concentration: 0.2mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNUB2051-50 50uL
EUR 486
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), 1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNUB2051-500 500uL
EUR 615.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), Concentration: 0.2mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNUB2062-100 100uL
EUR 316.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), Concentration: 0.2mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNUB2062-50 50uL
EUR 486
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), 1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNUB2062-500 500uL
EUR 615.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), Concentration: 0.2mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNUB2085-100 100uL
EUR 316.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), Concentration: 0.2mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNUB2085-50 50uL
EUR 486
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), 1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNUB2085-500 500uL
EUR 615.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), Concentration: 0.2mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC472051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF647 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC472051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF647 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC472062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF647 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC472062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF647 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC472085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF647 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC472085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF647 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC552062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF555 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody

BNC552062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF555 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC552085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF555 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody

BNC552085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF555 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody

BNC612051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF660R conjugate, Concentration: 0.1mg/mL

Furthermore, RA patients with low baseline serum miR-15a / 16 levels now the poor response of the 3-month disease-modifying antirheumatic drugs (DMARDs) therapy. Collectively, these studies revealed that miR-15a / 16 / SOX5 axis serves as the main driver of RA-FLSs invasion, migration and inflammatory responses in each negative feedback and correlated with treatment response to DMARDs in RA.

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