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MicroRNA-495 attenuates proliferation and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through attenuating β-catenin pathway

MicroRNA-495 attenuates proliferation and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through attenuating β-catenin pathway

Fibroblast like synoviocytes (FLSs) exert important effects in the occurrence and progression of rheumatoid arthritis (RA). MicroRNA-495 (miR-495) can regulate growth behavior of many cell types. Nevertheless, the role of miR-495 is still unclear in RA-FLS. We aim to explore the role and molecular mechanism of miR-495 in RA. The FLSs and synovial tissue from normal and RA cases were used in this study. RT-PCR analysis was used to test the expression of miR-495. Western blot assay was performed to determine the levels of matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-2 (MMP-2) and β-catenin.

Cell counting kit-8 (CCK-8) tests were performed to determine the proliferation of RA-FLS in the different treatment groups. The results showed that miR-495 down-regulated in the synovial tissue and RA-RA-FLSs. Overexpression of miR-495 can inhibit RA-FLS proliferation and inflammatory factor interleukin (IL) -6, IL-11 and tumor necrosis factor alpha (TNF-α), and the lower the protein expression of MMP-9 and MMP-2. In addition, miR-495 could negatively regulates the expression of β-catenin in RA-FLSs.

We also confirmed that the role of inhibition of miR-495 in RA-FLS is through the regulation of β-catenin expression. Taken together, miR-495 is downregulated in RA-FLS and RA synovial tissue, and miR-495 inhibits proliferation and the inflammatory response in RA-FLS, partly through regulating the expression of β-catenin. The miR-495 / β-catenin signaling pathway may serve as a new therapeutic target for RA.
mir-483-3p was upregulated in RA, which is explicitly promoted cell proliferation, induction of the transition phase G0 / G1-to-S, and suppressed apoptosis in RA FLSs, whereas silencing of miR-483-3p produce the opposite result.

In addition, insulin growth factor 1 (IGF-1) is detected as a direct target of miR-483-3p. IGF-1 silencing partially restored cell proliferation, the transition phase G0 / G1-to-S, and suppression of apoptosis in RA FLSs through inhibition of miR-483-3p. Our results show that miR-483-3p RA FLSs promote proliferation by targeting the IGF-1, indicating a potential strategy for diagnostic and treatment strategies for RA.

MicroRNA-495 attenuates proliferation and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through attenuating β-catenin pathway
MicroRNA-495 attenuates proliferation and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through attenuating β-catenin pathway

MicroRNA-15a / 16 / SOX5 axis promotes migration, invasion and the inflammatory response in rheumatoid arthritis fibroblast like synoviocytes

Fibroblast like synoviocytes (FLSs) is a key effector cells in the pathogenesis of rheumatoid arthritis (RA) and featuring aggressive tumor phenotype is unique with exceptional hyperplasia, increased cell migration and invasion. How FLSs experiencing this change in RA remains unknown. We previously reported a novel function of transcription factors in RA SOX5-FLSs that promote cell migration and invasion.

In this study, we found that miR-15a / 16 directly target and suppress the expression of the 3’UTR SOX5 SOX5. In addition, miR-15a / 16 was significantly down-regulated in RA-FLSs, which is negatively correlated with the expression SOX5. Transfection with miR-15a / 16 mimic the RA-FLSs cell migration inhibiting, invasion, IL-1β and TNF expression. SOX5 expression in RA-FLSs decreased miR-15a / 16 expression and rescue miR-15a / 16-mediated inhibitory effect.

Human Bone Marrow CD34+ Stem Cells, Cryopreserved
BMCD34-C0.5M - Ask for price

Human Bone Marrow CD34+ Stem Cells, Cryopreserved
BMCD34-C1M - Ask for price

Human Bone Marrow CD34+ Stem Cells, Cryopreserved
BMCD34-C5M - Ask for price

Human Peripheral Blood CD3+ T Cells, Cryopreserved
PBCD3-C10M - Ask for price

Human Peripheral Blood CD3+ T Cells, Cryopreserved
PBCD3-C20M - Ask for price

Human Cord Blood CD34+ Cells, Cryopreserved, single donor
CBCD34-C0.5M - Ask for price

Human Cord Blood CD34+ Cells, Cryopreserved, mixed donor 
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Human Cord Blood CD34+ Cells, Cryopreserved, mixed donor 
CBCD34mix-C1M - Ask for price

Human Cord Blood CD34+ Cells, Cryopreserved, mixed donor 
CBCD34mix-C5M - Ask for price

Human Cord Blood CD34+ Cells, Cryopreserved, single donor 
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Human Normal Peripheral Blood Mononuclear Cells (PBMC), Cryopreserved
PBMC-C100M - Ask for price

Human Normal Peripheral Blood Mononuclear Cells (PBMC), Cryopreserved
PBMC-C10M - Ask for price

Human Normal Peripheral Blood Mononuclear Cells (PBMC), Cryopreserved
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Human Normal Peripheral Blood Mononuclear Cells (PBMC), Cryopreserved
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Human  Peripheral  Blood  CD4+  T  Lymphocytes, Cryopreserved
PBCD4-C10M - Ask for price

Human  Peripheral  Blood  CD14+ Monocytes, Cryopreserved / Untouched
PBCD14U-C10M - Ask for price

Human Normal Peripheral Blood CD4+/CD25+ Regulatory T Cells (T reg), Cryopreserved
PBCD4-25-C2M - Ask for price

Human  Peripheral  Blood  CD14+ Monocytes, Cryopreserved / Positive selection
PBCD14P-C10M - Ask for price

Positively Selected Normal Peripheral Blood CD19+ B Cells, Cryopreserved
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Endothelial Cryopreserve Media
FM300 10 ml
EUR 308.4

CRYOPRESERVATION BAG, 50ML
91-200-88 1/pk
EUR 97.2
Description: Flexible Containers; Bioprocess Bags and Parts

CRYOPRESERVATION BAG, 250ML
91-200-89 1/pk
EUR 100.8
Description: Flexible Containers; Bioprocess Bags and Parts

CRYOPRESERVATION BAG, 500ML
91-200-90 1/pk
EUR 104.4
Description: Flexible Containers; Bioprocess Bags and Parts

CRYOPRESERVATION BAG, 750ML
91-200-91 1/pk
EUR 108
Description: Flexible Containers; Bioprocess Bags and Parts

Cryopreservation Medium For Human Embryonic Stem Cells
HUXES-07031 20/50mL Ask for price

AddexBio Cryopreservation Medium
C0002-20mL RT vial
EUR 124.8

Cryopreservation Medium For General Use
CYRO-10001 20/50mL Ask for price

NCR Cryopreservation Medium For General Use
NCRC-10001 20/50mL Ask for price

Cryopreservation Medium For Neural Stem Cells
GUXNX-07031 20/50mL Ask for price

NCR Protein-Free Cryopreservation Medium For General Use
NCPF-10001 20/50mL Ask for price

Chemical Defined Xeno-free Cell Cryopreservation Medium
abx298009-20ml 20 ml
EUR 292.8

NCR Protein-Free Cryopreservation Medium For Neural Stem Cells
GUXNX-07021 20/50mL Ask for price

COOLCELL SV2 STEMCELL CRYOPRESERVATION SYSTEM INCLUDES THE XT STARTER BENCHTOP COOLER, COOLRACK SV2 AND COOLCELL SV2 CELL FREEZING CONTAINER FOR 12 INJECTABLE VIALS
432012 1/pk
EUR 1024.8
Description: BioCision; BioCision CoolCell

COOLCELL SV10 STEMCELL CRYOPRESERVATION SYSTEM INCLUDES THE XT STARTER BENCHTOP COOLER, COOLRACK SV10 AND COOLCELL SV10 CELL FREEZING CONTAINER FOR 6 INJECTABLE VIALS
432013 1/pk
EUR 1024.8
Description: BioCision; BioCision CoolCell

Total RNA - Human Tumor Tissue: Synoviosarcoma
R1235257-10 10 ug
EUR 400

Total Protein - Human Tumor Tissue: Synoviosarcoma
P1235257 1 mg
EUR 471

Human E3 ubiquitin- protein ligase synoviolin, SYVN1 ELISA KIT
ELI-29339h 96 Tests
EUR 988.8

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
abx383609-96tests 96 tests
EUR 1093.2

ELISA kit for Human E3 ubiquitin-protein ligase synoviolin (SYVN1)
KTE60446-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Human E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human E3 ubiquitin-protein ligase synoviolin (SYVN1)
KTE60446-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Human E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human E3 ubiquitin-protein ligase synoviolin (SYVN1)
KTE60446-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Synovial Apoptosis Inhibitor 1, Synoviolin Antibody
20-abx115960
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

E3 Ubiquitin-Protein Ligase Synoviolin (HRD1) Antibody
abx031572-400ul 400 ul
EUR 627.6

E3 Ubiquitin-Protein Ligase Synoviolin (HRD1) Antibody
abx031572-80l 80 µl
EUR 343.2

Mouse E3 ubiquitin- protein ligase synoviolin, Syvn1 ELISA KIT
ELI-23703m 96 Tests
EUR 1038

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx238463-100ug 100 ug
EUR 610.8

E3 ubiquitin-protein ligase synoviolin (SYVN1) Antibody
20-abx211798
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx025097-400ul 400 ul
EUR 627.6

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx025097-80l 80 µl
EUR 343.2

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx025098-400ul 400 ul
EUR 627.6

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx025098-80l 80 µl
EUR 343.2

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx431931-200ul 200 ul
EUR 460.8

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx431932-200ul 200 ul
EUR 460.8

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
20-abx002034
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
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E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
20-abx302155
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (HRP)
20-abx314566
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
abx390695-96tests 96 tests
EUR 1093.2

Syvn1 ELISA Kit| Mouse E3 ubiquitin-protein ligase synoviolin E
EF016338 96 Tests
EUR 826.8

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (FITC)
20-abx314567
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

ELISA kit for Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1)
KTE70316-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1)
KTE70316-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1)
KTE70316-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (Biotin)
20-abx314568
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Nori® Human IL-12 ELISA Kit- Synovial Fluid
GR106141-SF 96-well
EUR 461

CryoProtX
M-MD1-61 46 x 1.5 ml ml
EUR 360
Description: CryoProtX

Nori® Human VEGF ELISA Kit- Synovial Fluid-2 Plates
GR111005-SF-2 2 x 96-well
EUR 832

Human Bone Joint PrimaCell: Normal Synovial Cell
2-96011 1 Kit Ask for price

Nori® Human IL-13 ELISA Kit- Synovial Fluid-2 Plates
GR111006-SF-2 2 x 96-well
EUR 832

CryoProtX Eco Screen
M-MD1-61-ECO 46 x 1.5 ml ml
EUR 360
Description: CryoProtX Eco Screen

Human Synovial Microvascular Endothelial Cells
HEC10 500,000+ Cells
EUR 1296

CryoProtX Mix Reagents 1.5 mL
M-MDSR-61 1.5 ml ml
EUR 37
Description: CryoProtX Mix Reagents 1.5 mL

CryoProtX Mix Eco Reagents 1.5 mL
M-MDSR-61-ECO 1.5 ml ml
EUR 37
Description: CryoProtX Mix Eco Reagents 1.5 mL

Paraffin Tissue Section - Human Bone Tumor: Synovial Sarcoma
T2235023-8 5 slides
EUR 238

Human Bone Joint PrimaCell: Normal Synovial Cells Growth Medium
9-46011 5 x 100 ml Ask for price

Human Bone Joint Tissue Preparation Buffer: Normal Synovial Cells
9-80011 1 x 100 ml Ask for price

SSX1 Synovial Sarcoma, X Breakpoint 1 Human Recombinant Protein
PROTQ16384 Regular: 10ug
EUR 380.4
Description: SSX1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 211 amino acids (1-188 a.a) and having a molecular mass of 24.3kDa.;SSX1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

SSX2 Synovial Sarcoma, X Breakpoint 2 Human Recombinant Protein
PROTQ16385 Regular: 10ug
EUR 380.4
Description: SSX2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 210 amino acids (1-188a.a) and having a molecular mass of 24.0kDa. ;SSX2 is fused to a 22 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

FD Tissue Cryoprotection Solution™
PC102 250 ml
EUR 156

20 x Synovial Fluid Solution
GR103059 100 mL
EUR 70

Mycoplasma synoviae PCR kit
PCR-M405-48D 50T
EUR 543.6

Mycoplasma synoviae PCR kit
PCR-M405-96D 100T
EUR 686.4

Mycoplasma synoviae RT PCR kit
RTq-M405-100D 100T
EUR 860.4

Mycoplasma synoviae RT PCR kit
RTq-M405-150D 150T
EUR 969.6

Mycoplasma synoviae RT PCR kit
RTq-M405-50D 50T
EUR 717.6

Human Bone Joint PrimaCell: Normal Synovial Cells Growth Supplements with Serum (for 500 ml medium)
9-47011 1 Set Ask for price

Synovial sarcoma tissue array
SS1001 each
EUR 348
Description: Synovial sarcoma tissue array, including TNM, clinical stage and pathology grade, 50 cases/100 cores

Mycoplasma synoviae One-Step PCR kit
Oneq-M405-100D 100T
EUR 1039.2

Mycoplasma synoviae One-Step PCR kit
Oneq-M405-150D 150T
EUR 1177.2

Mycoplasma synoviae One-Step PCR kit
Oneq-M405-50D 50T
EUR 861.6

Nori® Canine (dog) IL-6 ELISA Kit- Synovial Fluid
GR106143-SF 96-well
EUR 461

Nori® Canine (dog) IL-12 ELISA Kit- Synovial Fluid
GR106142-SF 96-well
EUR 461

Nori® Rat VEGF ELISA Kit- Synovial Fluid-2 Plates
GR-118002-SF-2 2 x 96-well
EUR 832

Synovial Sarcoma, X Breakpoint 1 Protein
20-abx262587
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Nori® Equine (horse) TLR3 ELISA Kit- Synovial Fluid
GR106098-SF 96-well
EUR 461

Nori® Equine (horse) IL-12 ELISA Kit- Synovial Fluid
GR106140-SF 96-well
EUR 461

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC942051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF594 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC942051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF594 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC942062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF594 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC942062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF594 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC942085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF594 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC942085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF594 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC802051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF680 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC802051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF680 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC802062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF680 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC802062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF680 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC802085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF680 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC802085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF680 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC702051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF770 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC702051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF770 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC702062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF770 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC702062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF770 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC702085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF770 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC702085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF770 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC882051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF488A conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC882051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF488A conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC882062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF488A conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC882062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF488A conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC882085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF488A conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC882085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF488A conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC812051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF680R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC812051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF680R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC812062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF680R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC812062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF680R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC812085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF680R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC812085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF680R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC052051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF405M conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC052051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF405M conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC052062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF405M conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC052062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF405M conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC052085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF405M conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC052085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF405M conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC042051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF405S conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC042051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF405S conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC042062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF405S conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC042062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF405S conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC042085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF405S conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC042085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF405S conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC402051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF640R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC402051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF640R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC402062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF640R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC402062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF640R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC402085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF640R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC402085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF640R conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNCAP2051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNCAP2051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNCAP2062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNCAP2062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNCAP2085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNCAP2085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNCA2051-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), APC conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNCA2062-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), APC conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNCA2085-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), APC conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNCP2051-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), PerCP conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNCP2062-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), PerCP conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNCP2085-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), PerCP conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNCR2051-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), RPE conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNCR2062-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), RPE conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNCR2085-250 250uL
EUR 472.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), RPE conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNCH2051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNCH2051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNCH2062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNCH2062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNCH2085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNCH2085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNCB2051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), Biotin conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNCB2051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), Biotin conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNCB2062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), Biotin conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNCB2062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), Biotin conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNCB2085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), Biotin conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNCB2085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), Biotin conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNUB2051-100 100uL
EUR 316.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), Concentration: 0.2mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNUB2051-50 50uL
EUR 486
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), 1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNUB2051-500 500uL
EUR 615.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), Concentration: 0.2mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNUB2062-100 100uL
EUR 316.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), Concentration: 0.2mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNUB2062-50 50uL
EUR 486
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), 1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNUB2062-500 500uL
EUR 615.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), Concentration: 0.2mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNUB2085-100 100uL
EUR 316.8
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), Concentration: 0.2mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNUB2085-50 50uL
EUR 486
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), 1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNUB2085-500 500uL
EUR 615.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), Concentration: 0.2mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC472051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF647 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC472051-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF647 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC472062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF647 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC472062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF647 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC472085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF647 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC472085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF647 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC552062-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF555 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2062) Antibody
BNC552062-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2062), CF555 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC552085-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF555 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2085) Antibody
BNC552085-500 500uL
EUR 654
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF555 conjugate, Concentration: 0.1mg/mL

TLE1 (Synovial Sarcoma Marker) (TLE1/2051) Antibody
BNC612051-100 100uL
EUR 279.6
Description: Primary antibody against TLE1 (Synovial Sarcoma Marker) (TLE1/2051), CF660R conjugate, Concentration: 0.1mg/mL

Furthermore, RA patients with low baseline serum miR-15a / 16 levels now the poor response of the 3-month disease-modifying antirheumatic drugs (DMARDs) therapy. Collectively, these studies revealed that miR-15a / 16 / SOX5 axis serves as the main driver of RA-FLSs invasion, migration and inflammatory responses in each negative feedback and correlated with treatment response to DMARDs in RA.

Shelby

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