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MicroRNA-495 attenuates proliferation and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through attenuating β-catenin pathway
Fibroblast like synoviocytes (FLSs) exert important effects in the occurrence and progression of rheumatoid arthritis (RA). MicroRNA-495 (miR-495) can regulate growth behavior of many cell types. Nevertheless, the role of miR-495 is still unclear in RA-FLS. We aim to explore the role and molecular mechanism of miR-495 in RA. The FLSs and synovial tissue from normal and RA cases were used i n this study. RT-PCR analysis was used to test the expression of miR-495. Western blot assay was performed to determine the levels of matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-2 (MMP-2) and β-catenin.
Cell counting kit-8 (CCK-8) tests were performed to determine the proliferation of RA-FLS in the different treatment groups. The results showed that miR-495 down-regulated in the synovial tissue and RA-RA-FLSs. Overexpression of miR-495 can inhibit RA-FLS proliferation and inflammatory factor interleukin ( IL) -6, IL-11 and tumor necrosis factor alpha (TNF-α), and the lower the protein expression of MMP-9 and MMP-2. In addition, miR-495 could negatively regulates the expression of β-catenin in RA-FLSs.
We also confirmed that the role of inhibition of miR-495 in RA-FLS is through the regulation of β-catenin expression. Taken together, miR-495 is downregulated in RA-FLS and RA synovial tissue, and miR-495 inhibits proliferation and the inflammatory response in RA-FLS, partly through regulating the expression of β-catenin. The miR-495 / β-catenin signaling pathway may serve as a new therapeutic target for RA. mir-483-3p was upregulated in RA, which is explicitly promoted cell proliferation, induction of the transition phase G0 / G1-to-S, and suppressed apoptosis in RA FLSs, whereas silencing of miR-483-3p produce the opposite result.
In addition, insulin growth factor 1 (IGF-1) is detected as a direct target of miR-483-3p. IGF-1 silencing partially restored cell proliferation, the transition phase G0 / G1-to-S, and suppression of apoptosis in RA FLSs through inhibition of miR-483-3p. Our results show that miR-483-3p RA FLSs promote proliferation by targeting the IGF-1, indicating a potential strategy for diagnostic and treatment strategies for RA.
MicroRNA-495 attenuates proliferation and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through attenuating β-catenin pathway
MicroRNA-15a / 16 / SOX5 axis promotes migration, invasion and the inflammatory response in rheumatoid arthritis fibroblast like synoviocytes
Fibroblast like synoviocytes (FLSs) is a key effector cells in the pathogenesis of rheumatoid arthritis (RA) and featuring aggressive tumor phenotype is unique with exceptional hyperplasia, increased cell migration and invasion. How FLSs experiencing this change in RA remains unknown. We previously reported a novel function of transcription factors in RA SOX5-FLSs that promote cell migration and invasion.
In this study, we found that miR-15a / 16 directly target and suppress the expression of the 3’UTR SOX5 SOX5. In addition, miR-15a / 16 was significantly down-regulated in RA-FLSs, which is negatively correlated with the expression SOX5. Transfection with miR-15a / 16 mimic the RA-FLSs cell migration inhibiting, invasion, IL-1β and TNF expression. SOX5 expression in RA-FLSs decreased miR-15a / 16 expression and rescue miR-15a / 16-mediated inhibitory effect.
Pooled Human Semen Cryopreserved
IRHUSMCRYP0.5ML
Innovative research
each
EUR 1170
Description: Pooled Human Semen Cryopreserved
Human Synoviocytes
ABC-TC3829
AcceGen
1 vial
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Description: Human synoviocytes (HS), the predominant cell type of healthy synovial tissue, are fibroblast-like cells. The Synoviocytes form a distinct structure called the synovial lining layer. Electron microscopy revealed extensive cell-to-cell contacts within the lining layer. The Synoviocytes produce synovial fluid components and are responsible for absorption from the joint cavity, and for blood/synovial fluid exchanges. The synoviocytes proliferate, show anchorage-independent growth, and also secrete a variety of effector molecules that promote inflammation and joint destruction and, themselves are part of a complex network of autocrine and paracrine acting factors. The synoviocytes express cadherin-11 providing new insight into synovial tissue organization and morphogenesis and of interest as a therapeutic target.HS from Gentaur Research Laboratories are isolated from human synovium. HS are cryopreserved at passage one cultures and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HS are characterized by their fibroblast-like morphology, growth pattern and immunocytochemistry of CD 90 and fibronectin. HS are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HS are guaranteed for 15 population doublings at the conditions provided by Gentaur Research Laboratories.
Human CD3+ T Cells (Pan T Cells), Cryopreserved
M1299-10
Biovision
each
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Human CD3+ T Cells (Pan T Cells), Cryopreserved
M1299-20
Biovision
each
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Human CD3+ T Cells (Pan T Cells), Cryopreserved
M1299-30
Biovision
each
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Human CD3+ T Cells (Pan T Cells), Cryopreserved
M1299-40
Biovision
each
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Human Fibroblast-Like Synoviocytes
cAP-0141
Angio Proteomie
1Frozen Vial
EUR 693
Immortalized Human Synoviocytes-SV40
CSC-I2279Z
Creative Bioarray
One Frozen vial
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Human fibroblast-like synoviocytes (HFLS)
P0004018
Addexbio
One Frozen vial
EUR 700
Human Cryopreserved Intervertebral Disc Cells, Healthy Donor: Annulus Fibrosus (AF)
CDD-H-2710-AF
Articular Engineering
1 vial
EUR 575
Human Cryopreserved Intervertebral Disc Cells, Healthy Donor: Nucleus Pulposus (NP)
CDD-H-2710-NP
Articular Engineering
1 vial
EUR 575
Positively Selected Normal Peripheral Blood CD19+ B Cells, Cryopreserved
PBCD19P-C10M
101Bio
-
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Human fibroblast-like synoviocytes: Rheumatoid Arthritis (HFLS-RA)
P0004019
Addexbio
One Frozen vial
EUR 700
Immortalized Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes-hTERT
CSC-I2074Z
Creative Bioarray
One Frozen vial
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Epithelial Cryopreserve Media
FM301
Neuromics
each
EUR 259.2
Human Synoviocyte Growth Medium
C0013-44
Addexbio
RT 500 mL Bottle
EUR 98
Cryopreservation Medium
For Human Embryonic Stem Cells
HUXES-07031
Cyagen
20/50mL
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CRYOPRESERVATION BAG, 50ML
91-200-88
CORNING
1/pk
EUR 97.2
Description: Flexible Containers; Bioprocess Bags and Parts
CRYOPRESERVATION BAG, 250ML
91-200-89
CORNING
1/pk
EUR 100.8
Description: Flexible Containers; Bioprocess Bags and Parts
CRYOPRESERVATION BAG, 500ML
91-200-90
CORNING
1/pk
EUR 104.4
Description: Flexible Containers; Bioprocess Bags and Parts
CRYOPRESERVATION BAG, 750ML
91-200-91
CORNING
1/pk
EUR 108
Description: Flexible Containers; Bioprocess Bags and Parts
Cryopreservation Medium
TM024
ABM
100ml
EUR 175
Serum Free Cryopreservation Medium
TM026
ABM
25 ml
EUR 50
Waymouth Cryopreservation Medium
0459
AthenaES
100 ml
EUR 21.8
AddexBio Cryopreservation Medium
C0002-01-20mL
Addexbio
RT vial
EUR 25
AddexBio Cryopreservation Medium
C0002-20mL
Addexbio
RT vial
EUR 124.8
Cryopreservation Medium For General Use
CYRO-10001
Cyagen
20/50mL
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NCR Cryopreservation Medium
For General Use
NCRC-10001
Cyagen
20/50mL
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Human Fibroblast-Like Synoviocyte Normal Tissue, Adult
ABC-TC3619
AcceGen
1 vial
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Description: Human Fibroblast-Like Synoviocytes (HFLS) are isolated from normal synovial tissues. They are cryopreserved at second passage and can be cultured and propagated at least 5 population doublings.
Cryopreservation Medium
For Neural Stem Cells
GUXNX-07031
Cyagen
20/50mL
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Human Fibroblast-Like Synoviocyte Osteo Arthritis, Adult
ABC-TC3620
AcceGen
1 vial
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Description: Human Fibroblast-Like Synoviocytes (HFLS) are isolated from synovial tissues obtained from patients with Rheumatoid Arthritis (RA) / Osteoarthritis (OA). They are cryopreserved at second passage and can be cultured and propagated at least 5 population doubling.
Serum-free cell cryopreservation solution
EGQA0073
EnoGene
100ml
EUR 80
Synoviocyte Growth Medium, Ready-to-Use, 500 ml, 10% Human Serum Supplement
M2700-10HS
Articular Engineering
500 ml bottle
EUR 120
Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult
ABC-TC3621
AcceGen
1 vial
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Description: Human Fibroblast-Like Synoviocytes (HFLS) are isolated from synovial tissues obtained from patients with Rheumatoid Arthritis (RA) / Osteoarthritis (OA). They are cryopreserved at second passage and can be cultured and propagated at least 5 population doubling.
NCR Protein-Free Cryopreservation Medium For General Use
NCPF-10001
Cyagen
20/50mL
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Synoviocyte Growth Medium, Ready-to-Use, 500 ml, 2% Human Serum Supplement Factors
M2700-2HS
Articular Engineering
500 ml bottle
EUR 120
Chemical Defined Xeno-free Cell Cryopreservation Medium
abx298009-20ml
Abbexa
20 ml
EUR 292.8
QuickFreezing-I Insect cell cryopreservation solution
E28X0310043-100
EnoGene
100ml
EUR 361.9
NCR Protein-Free Cryopreservation Medium
For Neural Stem Cells
GUXNX-07021
Cyagen
20/50mL
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QuickFreezing-M Mammalian cell cryopreservation solution
E28X0310041-100
EnoGene
100ml
EUR 184.13
QuickFreezing-M Mammalian cell cryopreservation solution
E28X0310041-30
EnoGene
30ml
EUR 69.84
QuickFreezing-2×M Mammalian cell cryopreservation solution
E28X0310042-100
EnoGene
100ml
EUR 361.9
QuickFreezing-2×M Mammalian cell cryopreservation solution
E28X0310042-30
EnoGene
30ml
EUR 133.33
COOLCELL SV2 STEMCELL CRYOPRESERVATION SYSTEM INCLUDES THE XT STARTER BENCHTOP COOLER, COOLRACK SV2 AND COOLCELL SV2 CELL FREEZING CONTAINER FOR 12 INJECTABLE VIALS
432012
CORNING
1/pk
EUR 1024.8
Description: BioCision; BioCision CoolCell
COOLCELL SV10 STEMCELL CRYOPRESERVATION SYSTEM INCLUDES THE XT STARTER BENCHTOP COOLER, COOLRACK SV10 AND COOLCELL SV10 CELL FREEZING CONTAINER FOR 6 INJECTABLE VIALS
432013
CORNING
1/pk
EUR 1024.8
Description: BioCision; BioCision CoolCell
Human Synovial Tissue, OA, FFPE
CDD-H-3000-ST-OA
Articular Engineering
1 H-E stained slide, 2 unstained slides
EUR 200
Human Synovial Tissue, OA, OCT frozen
CDD-H-3000-OCT-ST-OA
Articular Engineering
Flash frozen tissue in OCT medium
EUR 250
Human Synovial Tissue Explant Culture, OA
CDD-H-2920-OA
Articular Engineering
Multiwell plate format
EUR 675
Human synovial apoptosis inhibitor 1, synoviolin(SYVN1) ELISA Kit
NSL2294Hu
Sunlong
96 wells
EUR 468
Total RNA - Human Tumor Tissue: Synoviosarcoma
R1235257-10
Biochain
10 ug
EUR 480
Total Protein - Human Tumor Tissue: Synoviosarcoma
P1235257
Biochain
1 mg
EUR 542
Human E3 ubiquitin- protein ligase synoviolin, SYVN1 ELISA KIT
ELI-29339h
Lifescience Market
96 Tests
EUR 988.8
SYVN1 (untagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1
SC324298
Origene Technologies GmbH
10 µg
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SYVN1 (untagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2
SC101046
Origene Technologies GmbH
10 µg
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SYVN1 (untagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1
SC309770
Origene Technologies GmbH
10 µg
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Human E3 ubiquitin-protein ligase synoviolin(SYVN1) Elisa Kit
EK713836
AFG Bioscience LLC
96 Wells
EUR 0.4
Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
EK6825
SAB
96Т
EUR 799
Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
abx383609-96tests
Abbexa
96 tests
EUR 1093.2
Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
AE16187HU-48Tests
Abebio
48 Tests
EUR 325
Description: Human (Homo sapiens)
Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
AE16187HU-96Tests
Abebio
96 Tests
EUR 610
Description: Human (Homo sapiens)
Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
KTE60446-48T
Abbkine
48T
EUR 339
Description: This Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.
Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
KTE60446-96T
Abbkine
96T
EUR 589
Description: This Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.
Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
KTE60446-96T5
Abbkine
96 T×5
EUR 2629
Description: This Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.
Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
KTE60446-96T50
Abbkine
96 T×50
EUR 24569
Description: This Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.
Human E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) ELISA Kit
abx383609-1096tests
Abbexa
10 × 96 tests
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Human E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) ELISA Kit
abx383609-596tests
Abbexa
5 × 96 tests
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SYVN1 (GFP-tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1
RG207132
Origene Technologies GmbH
10 µg
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SYVN1 (GFP-tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2
RG220540
Origene Technologies GmbH
10 µg
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ELISA kit for Human E3 ubiquitin-protein ligase synoviolin (SYVN1)
KTE60446-5platesof96wells
Abbkine
5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Human E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
SYVN1 (Myc-DDK-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2
RC220540
Origene Technologies GmbH
10 µg
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SYVN1 (Myc-DDK-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1
RC207132
Origene Technologies GmbH
10 µg
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Human E3 ubiquitin-Protein Ligase synoviolin, SYVN1 GENLISA ELISA
KBH5217
Krishgen
1 x 96 wells
EUR 286
Lenti ORF clone of Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, mGFP tagged
RC220540L2
Origene Technologies GmbH
10 µg
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Lenti ORF clone of Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, mGFP tagged
RC220540L4
Origene Technologies GmbH
10 µg
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Lenti ORF clone of Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, Myc-DDK-tagged
RC220540L1
Origene Technologies GmbH
10 µg
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Lenti ORF clone of Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, Myc-DDK-tagged
RC220540L3
Origene Technologies GmbH
10 µg
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Lenti-ORF clone of SYVN1 (mGFP-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1
RC207132L4
Origene Technologies GmbH
10 µg
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Lenti-ORF clone of SYVN1 (Myc-DDK-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1
RC207132L3
Origene Technologies GmbH
10 µg
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Lenti ORF particles, SYVN1 (mGFP-tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, 200ul, >10^7 TU/mL
RC220540L2V
Origene Technologies GmbH
200 µl
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Lenti ORF particles, SYVN1 (mGFP-tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, 200ul, >10^7 TU/mL
RC220540L4V
Origene Technologies GmbH
200 µl
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Lenti ORF particles, SYVN1 (mGFP-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1, 200ul, >10^7 TU/mL
RC207132L4V
Origene Technologies GmbH
200 µl
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Lenti ORF particles, SYVN1 (Myc-DDK tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, 200ul, >10^7 TU/mL
RC220540L1V
Origene Technologies GmbH
200 µl
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Lenti ORF particles, SYVN1 (Myc-DDK tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, 200ul, >10^7 TU/mL
RC220540L3V
Origene Technologies GmbH
200 µl
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Human Synovial Tissue Explant Culture, OA with wet weight determination provided for each explant in Excel spreadsheet
CDD-H-2920-OA-WW
Articular Engineering
Multiwell plate format
EUR 875
Lenti ORF particles, SYVN1 (Myc-DDK-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1, 200ul, >10^7 TU/mL
RC207132L3V
Origene Technologies GmbH
200 µl
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Synovial Apoptosis Inhibitor 1, Synoviolin Antibody
20-abx115960
Abbexa
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Synovial Apoptosis Inhibitor 1, Synoviolin Antibody
abx115960-100g
Abbexa
100 µg
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Synovial Apoptosis Inhibitor 1, Synoviolin Antibody
abx115960-10g
Abbexa
10 µg
EUR 612.5
Synovial Apoptosis Inhibitor 1, Synoviolin Antibody
abx115960-200g
Abbexa
200 µg
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Syvn1 (untagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), (10 ug)
RN210996
Origene Technologies GmbH
10 µg
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Syvn1 (GFP-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1)
MG209408
Origene Technologies GmbH
10 µg
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Syvn1 (Myc-DDK-tagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), (10 ug)
RR210996
Origene Technologies GmbH
10 µg
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Lenti ORF clone of Syvn1 (mGFP-tagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), (10 ug)
RR210996L4
Origene Technologies GmbH
10 µg
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Lenti ORF clone of Syvn1 (Myc-DDK-tagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), (10 ug)
RR210996L3
Origene Technologies GmbH
10 µg
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Human Synovial Fluid
ABC-TC3824
AcceGen
1 vial
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Description: Human synovial tissue and fluid are isolated from a single donor. This fluid has been frozen fresh. Synovial tissue and fluid can enable your knowledge of disease mechanisms and allows you to correlate clinical symptoms with pathology. Most importantly these observations may lead to the discovery of new therapeutic targets in arthritis disease.Development period: Postnatal
Syvn1 (untagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1, (10ug)
MC204599
Origene Technologies GmbH
10 µg
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Lenti ORF particles, Syvn1 (Myc-DDK-tagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), 200ul, >10^7 TU/mL
RR210996L3V
Origene Technologies GmbH
200 µl
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Lenti ORF particles, Syvn1 (GFP-tagged ORF) - Rat synovial apoptosis inhibitor 1, synoviolin (Syvn1), 200ul, >10^7 TU/mL
RR210996L4V
Origene Technologies GmbH
200 µl
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Syvn1 (GFP-tagged) - Mouse synovial apoptosis inhibitor 1 synoviolin (Syvn1) transcript variant 2, (10ug)
MG219322
Origene Technologies GmbH
10 µg
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Mouse E3 ubiquitin- protein ligase synoviolin, Syvn1 ELISA KIT
ELI-23703m
Lifescience Market
96 Tests
EUR 1038
E3 Ubiquitin-Protein Ligase Synoviolin (HRD1) Antibody
abx031572-400ul
Abbexa
400 ul
EUR 627.6
E3 Ubiquitin-Protein Ligase Synoviolin (HRD1) Antibody
abx031572-80l
Abbexa
80 µl
EUR 343.2
E3 Ubiquitin-Protein Ligase Synoviolin (HRD1) Antibody
abx031572-400l
Abbexa
400 µl
EUR 518.75
CryoProtX
M-MD1-61
MiTeGen
46 x 1.5 ml ml
EUR 360
Description: CryoProtX
Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1
MR209408
Origene Technologies GmbH
10 µg
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Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 2
MR219322
Origene Technologies GmbH
10 µg
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E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx431931-200ul
Abbexa
200 ul
EUR 460.8
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx431932-200ul
Abbexa
200 ul
EUR 460.8
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
20-abx302155
Abbexa
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100 ug
1 mg
200 ug
20 ug
50 ug
E3 ubiquitin-protein ligase synoviolin (SYVN1) Antibody
20-abx211798
Abbexa
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E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx238463-100ug
Abbexa
100 ug
EUR 610.8
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
20-abx002034
Abbexa
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100 ul
200 ul
20 ul
50 ul
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx025097-400ul
Abbexa
400 ul
EUR 627.6
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx025097-80l
Abbexa
80 µl
EUR 343.2
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx025098-400ul
Abbexa
400 ul
EUR 627.6
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx025098-80l
Abbexa
80 µl
EUR 343.2
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx002034-100l
Abbexa
100 µl
EUR 400
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx002034-20l
Abbexa
20 µl
EUR 175
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx002034-50l
Abbexa
50 µl
EUR 275
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx302155-100g
Abbexa
100 µg
EUR 362.5
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx302155-20g
Abbexa
20 µg
EUR 162.5
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx302155-50g
Abbexa
50 µg
EUR 250
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx025097-400l
Abbexa
400 µl
EUR 518.75
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx025098-400l
Abbexa
400 µl
EUR 518.75
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx238463-100g
Abbexa
100 µg
EUR 350
E3 ubiquitin-protein ligase synoviolin (SYVN1) Antibody
abx211798-100l
Abbexa
100 µl
EUR 350
E3 ubiquitin-protein ligase synoviolin (SYVN1) Antibody
abx211798-50l
Abbexa
50 µl
EUR 250
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx431931-100g
Abbexa
100 µg
EUR 387.5
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
abx431932-100g
Abbexa
100 µg
EUR 387.5
Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
EK6826
SAB
96Т
EUR 799
Syvn1 ELISA Kit| Mouse E3 ubiquitin-protein ligase synoviolin E
EF016338
Lifescience Market
96 Tests
EUR 826.8
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (HRP)
20-abx314566
Abbexa
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100 ug
1 mg
200 ug
20 ug
50 ug
Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
abx390695-96tests
Abbexa
96 tests
EUR 1093.2
Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
AE16188MO-48Tests
Abebio
48 Tests
EUR 325
Description: Mouse (Mus musculus)
Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
AE16188MO-96Tests
Abebio
96 Tests
EUR 610
Description: Mouse (Mus musculus)
Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
KTE70316-48T
Abbkine
48T
EUR 339
Description: This Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.
Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
KTE70316-96T
Abbkine
96T
EUR 589
Description: This Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.
Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
KTE70316-96T5
Abbkine
96 T×5
EUR 2629
Description: This Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.
Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
KTE70316-96T50
Abbkine
96 T×50
EUR 24569
Description: This Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.
Mouse E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) ELISA Kit
abx390695-1mg
Abbexa
1 mg
EUR 687.5
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (HRP)
abx314566-100g
Abbexa
100 µg
EUR 362.5
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (HRP)
abx314566-20g
Abbexa
20 µg
EUR 162.5
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (HRP)
abx314566-50g
Abbexa
50 µg
EUR 250
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (FITC)
20-abx314567
Abbexa
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100 ug
1 mg
200 ug
20 ug
50 ug
ELISA kit for Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1)
KTE70316-5platesof96wells
Abbkine
5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Mouse E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (FITC)
abx314567-100g
Abbexa
100 µg
EUR 362.5
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (FITC)
abx314567-20g
Abbexa
20 µg
EUR 162.5
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (FITC)
abx314567-50g
Abbexa
50 µg
EUR 250
3`UTR clone of synovial apoptosis inhibitor 1 synoviolin (SYVN1) transcript variant 1 for miRNA target validation
SC212618
Origene Technologies GmbH
10 µg
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3`UTR clone of synovial apoptosis inhibitor 1 synoviolin (SYVN1) transcript variant 2 for miRNA target validation
SC212619
Origene Technologies GmbH
10 µg
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Lenti ORF clone of Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1
MR209408L3
Origene Technologies GmbH
10 µg
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Lenti ORF clone of Syvn1 (mGFP-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1
MR209408L4
Origene Technologies GmbH
10 µg
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Lenti ORF clone of Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 2
MR219322L3
Origene Technologies GmbH
10 µg
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Lenti ORF clone of Syvn1 (mGFP-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 2
MR219322L4
Origene Technologies GmbH
10 µg
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Human Synovial Tissue, RA, FFPE
CDD-H-3000-ST-RA
Articular Engineering
1 H-E stained slide, 2 unstained slides
EUR 200
Human Synovial Stromal Cells
ABC-TC3826
AcceGen
1 vial
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Description: Primary Human Synovial Stromal Cells were initiated by elutriation from normal human synovial tissue.These cells were originated using Complete Serum-Free Medium Kit With AcceSup™, are available at <12 Cumulative Population Doublings (CPD) in vitro [Passage 3] and were cryopreserved in aliquots of ~1.5×10^6 cells. This vial will initiate a Passage 4 cell culture in a 75cm2 flask.
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (Biotin)
20-abx314568
Abbexa
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100 ug
1 mg
200 ug
20 ug
50 ug
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (Biotin)
abx314568-100g
Abbexa
100 µg
EUR 362.5
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (Biotin)
abx314568-20g
Abbexa
20 µg
EUR 162.5
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody (Biotin)
abx314568-50g
Abbexa
50 µg
EUR 250
Lenti ORF particles, Syvn1 (GFP-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1, 200ul, >10^7 TU/mL
MR209408L4V
Origene Technologies GmbH
200 µl
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Lenti ORF particles, Syvn1 (GFP-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 2, 200ul, >10^7 TU/mL
MR219322L4V
Origene Technologies GmbH
200 µl
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CryoProtX Eco Screen
M-MD1-61-ECO
MiTeGen
46 x 1.5 ml ml
EUR 360
Description: CryoProtX Eco Screen
Human Synovial Tissue, RA, OCT frozen
CDD-H-3000-OCT-ST-RA
Articular Engineering
Flash frozen tissue in OCT medium
EUR 250
Single Donor Human Synovial Fluid
IRHUSYNS1ML
Innovative research
each
EUR 427
Description: Single Donor Human Synovial Fluid
Human Synovial Tissue, Normal, FFPE
CDD-H-3000-ST-N
Articular Engineering
1 H-E stained slide, 2 unstained slides
EUR 200
Lenti ORF particles, Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1, 200ul, >10^7 TU/mL
MR209408L3V
Origene Technologies GmbH
200 µl
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Lenti ORF particles, Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 2, 200ul, >10^7 TU/mL
MR219322L3V
Origene Technologies GmbH
200 µl
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CryoProtX Mix Reagents 1.5 mL
M-MDSR-61
MiTeGen
1.5 ml ml
EUR 37
Description: CryoProtX Mix Reagents 1.5 mL
Furthermore, RA patients with low baseline serum miR-15a / 16 levels now the poor response of the 3-month disease-modifying antirheumatic drugs (DMARDs) therapy. Collectively, these studies revealed that miR-15a / 16 / SOX5 axis serves as the main driver of RA-FLSs invasion, migration and inflammatory responses in each negative feedback and correlated with treatment response to DMARDs in RA.