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MicroRNA-495 attenuates proliferation and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through attenuating β-catenin pathway

MicroRNA-495 attenuates proliferation and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through attenuating β-catenin pathway

Fibroblast like synoviocytes (FLSs) exert important effects in the occurrence and progression of rheumatoid arthritis (RA). MicroRNA-495 (miR-495) can regulate growth behavior of many cell types. Nevertheless, the role of miR-495 is still unclear in RA-FLS. We aim to explore the role and molecular mechanism of miR-495 in RA. The FLSs and synovial tissue from normal and RA cases were used in this study. RT-PCR analysis was used to test the expression of miR-495. Western blot assay was performed to determine the levels of matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-2 (MMP-2) and β-catenin.

Cell counting kit-8 (CCK-8) tests were performed to determine the proliferation of RA-FLS in the different treatment groups. The results showed that miR-495 down-regulated in the synovial tissue and RA-RA-FLSs. Overexpression of miR-495 can inhibit RA-FLS proliferation and inflammatory factor interleukin (IL) -6, IL-11 and tumor necrosis factor alpha (TNF-α), and the lower the protein expression of MMP-9 and MMP-2. In addition, miR-495 could negatively regulates the expression of β-catenin in RA-FLSs.

We also confirmed that the role of inhibition of miR-495 in RA-FLS is through the regulation of β-catenin expression. Taken together, miR-495 is downregulated in RA-FLS and RA synovial tissue, and miR-495 inhibits proliferation and the inflammatory response in RA-FLS, partly through regulating the expression of β-catenin. The miR-495 / β-catenin signaling pathway may serve as a new therapeutic target for RA.
mir-483-3p was upregulated in RA, which is explicitly promoted cell proliferation, induction of the transition phase G0 / G1-to-S, and suppressed apoptosis in RA FLSs, whereas silencing of miR-483-3p produce the opposite result.

In addition, insulin growth factor 1 (IGF-1) is detected as a direct target of miR-483-3p. IGF-1 silencing partially restored cell proliferation, the transition phase G0 / G1-to-S, and suppression of apoptosis in RA FLSs through inhibition of miR-483-3p. Our results show that miR-483-3p RA FLSs promote proliferation by targeting the IGF-1, indicating a potential strategy for diagnostic and treatment strategies for RA.

MicroRNA-495 attenuates proliferation and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through attenuating β-catenin pathway
MicroRNA-495 attenuates proliferation and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through attenuating β-catenin pathway

MicroRNA-15a / 16 / SOX5 axis promotes migration, invasion and the inflammatory response in rheumatoid arthritis fibroblast like synoviocytes

Fibroblast like synoviocytes (FLSs) is a key effector cells in the pathogenesis of rheumatoid arthritis (RA) and featuring aggressive tumor phenotype is unique with exceptional hyperplasia, increased cell migration and invasion. How FLSs experiencing this change in RA remains unknown. We previously reported a novel function of transcription factors in RA SOX5-FLSs that promote cell migration and invasion.

In this study, we found that miR-15a / 16 directly target and suppress the expression of the 3’UTR SOX5 SOX5. In addition, miR-15a / 16 was significantly down-regulated in RA-FLSs, which is negatively correlated with the expression SOX5. Transfection with miR-15a / 16 mimic the RA-FLSs cell migration inhibiting, invasion, IL-1β and TNF expression. SOX5 expression in RA-FLSs decreased miR-15a / 16 expression and rescue miR-15a / 16-mediated inhibitory effect.

Human Cryopreserved Bone Cells, OA
CDD-H-2810-OA 1 vial
EUR 600

Human Cryopreserved Tendon Cells
CDD-H-2465 1 vial
EUR 575

Pooled Human Semen Cryopreserved
IRHUSMCRYP0.5ML each
EUR 1170
Description: Pooled Human Semen Cryopreserved

Pooled Human Semen Cryopreserved
MBS8421299-05mL 0.5mL
EUR 1400

Pooled Human Semen Cryopreserved
MBS8421299-5x05mL 5x0.5mL
EUR 6075

Human Cryopreserved Bone Cells, RA
CDD-H-2810-RA 1 vial
EUR 600

Human Cryopreserved Chondrocytes, RA
CDD-H-2610-RA 1 vial
EUR 575

Human Cryopreserved Bone Cells, Normal
CDD-H-2810-N 1 vial
EUR 600

Human Cryopreserved Chondrocytes, Normal
CDD-H-2610-N 1 vial
EUR 575

Human Cryopreserved Ligament Cells, ACL
CDD-H-2475-ACL 1 vial
EUR 575

Human Cryopreserved Ligament Cells, PCL
CDD-H-2475-PCL 1 vial
EUR 575

Human Synoviocytes
ABC-TC3829 1 vial Ask for price
Description: Human synoviocytes (HS), the predominant cell type of healthy synovial tissue, are fibroblast-like cells. The Synoviocytes form a distinct structure called the synovial lining layer. Electron microscopy revealed extensive cell-to-cell contacts within the lining layer. The Synoviocytes produce synovial fluid components and are responsible for absorption from the joint cavity, and for blood/synovial fluid exchanges. The synoviocytes proliferate, show anchorage-independent growth, and also secrete a variety of effector molecules that promote inflammation and joint destruction and, themselves are part of a complex network of autocrine and paracrine acting factors. The synoviocytes express cadherin-11 providing new insight into synovial tissue organization and morphogenesis and of interest as a therapeutic target.HS from Gentaur Research Laboratories are isolated from human synovium. HS are cryopreserved at passage one cultures and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HS are characterized by their fibroblast-like morphology, growth pattern and immunocytochemistry of CD 90 and fibronectin. HS are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HS are guaranteed for 15 population doublings at the conditions provided by Gentaur Research Laboratories.

Human Bone Marrow MNCs, cryopreserved, 200 million
LO2M-125A each Ask for price

Human Bone Marrow MNCs, cryopreserved, 300 million
LO2M-125E each
EUR 5588.98

Human Cryopreserved Dermal Fibroblast Cells
CDD-H-2510 1 vial
EUR 575

Human CD3+ T Cells (Pan T Cells), Cryopreserved
M1299-10 each Ask for price

Human CD3+ T Cells (Pan T Cells), Cryopreserved
M1299-20 each Ask for price

Human CD3+ T Cells (Pan T Cells), Cryopreserved
M1299-30 each Ask for price

Human CD3+ T Cells (Pan T Cells), Cryopreserved
M1299-40 each Ask for price

Human Bone Marrow MNCs, cryopreserved, 25 million
LO2M-125C each
EUR 653.68

hum. Adult Melanocytes cryopreserved ,
LOCC-2586 each
EUR 1083.07

Cryopreserved Rat Microglia cells
LOR-G-535 each
EUR 1570.82

Rat Cryopreserved Chondrocytes, P2
CDD-R-2610 1 vial
EUR 575

InEpC (Human Intestinal Epithelial Cells), cryopreserved
LOCC-2931 each
EUR 1790.15

Human Bone Marrow MNCs, cryopreserved, 5 x 25 million
LO2M-125B each
EUR 2083.13

Human Bone Marrow MNCs, cryopreserved, 5 million cells
LO2S-101D each
EUR 667.34

S-ALI guaranteed SAEC, cryopreserved
LOCC-2547S each
EUR 1969.59

Human Osteoclast Precursors, cryopreserved, 1 million cells
LO2T-110 each
EUR 2034.39

Human NK Cells (neg. selection) cryopreserved , 5 million cells
LO2W-501 each
EUR 1874.06

Human NK Cells (pos. selection) cryopreserved , 5 million cells
LO2W-502 each
EUR 1650.78

Human Fibroblast-Like Synoviocytes
cAP-0141 1Frozen Vial
EUR 693

Immortalized Human Synoviocytes-SV40
CSC-I2279Z One Frozen vial Ask for price

Human fibroblast-like synoviocytes (HFLS)
P0004018 One Frozen vial
EUR 700

Synoviocytes Growth Medium
cAP-68 500ml
EUR 148.5

Mesenchymal Stem Cells, Mouse, Normal, Cryopreserved (mMSC)
MBS652609-500KCells 500KCells
EUR 1145

Mesenchymal Stem Cells, Mouse, Normal, Cryopreserved (mMSC)
MBS652609-5x500KCells 5x500KCells
EUR 4930

Cryopreserved Rat Embryonic Dorsal Root Ganglion Neurons
LOR-EDRG-515 each
EUR 1562.97

Human Cryopreserved Intervertebral Disc Cells, Healthy Donor: Annulus Fibrosus (AF)
CDD-H-2710-AF 1 vial
EUR 575

Human Cryopreserved Intervertebral Disc Cells, Healthy Donor: Nucleus Pulposus (NP)
CDD-H-2710-NP 1 vial
EUR 575

Semen - Cryopreserved; Cryogenically Preserved Semen (Motile Sperm)
MBS173696-05mL 0.5mL
EUR 1095

Semen - Cryopreserved; Cryogenically Preserved Semen (Motile Sperm)
MBS173696-5x05mL 5x0.5mL
EUR 4720

Rat Cerebellar Neurons (Granule Cells), cryopreserved, >4 million cells
LOR-CB-503 each
EUR 965.79

Positively Selected Normal Peripheral Blood CD19+ B Cells, Cryopreserved
PBCD19P-C10M - Ask for price

Human fibroblast-like synoviocytes: Rheumatoid Arthritis (HFLS-RA)
P0004019 One Frozen vial
EUR 700

Immortalized Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes-hTERT
CSC-I2074Z One Frozen vial Ask for price

Epithelial Cryopreserve Media
FM301 each
EUR 259.2

Endothelial Cryopreserve Media
MBS555799-10mL 10mL
EUR 275

Endothelial Cryopreserve Media
MBS555799-5x10mL 5x10mL
EUR 1090

Human Synoviocyte Growth Medium
C0013-44 RT 500 mL Bottle
EUR 98

Cryopreservation Medium For Human Embryonic Stem Cells
HUXES-07031 20/50mL Ask for price

CRYOPRESERVATION BAG, 50ML
91-200-88 1/pk
EUR 97.2
Description: Flexible Containers; Bioprocess Bags and Parts

CRYOPRESERVATION BAG, 250ML
91-200-89 1/pk
EUR 100.8
Description: Flexible Containers; Bioprocess Bags and Parts

CRYOPRESERVATION BAG, 500ML
91-200-90 1/pk
EUR 104.4
Description: Flexible Containers; Bioprocess Bags and Parts

CRYOPRESERVATION BAG, 750ML
91-200-91 1/pk
EUR 108
Description: Flexible Containers; Bioprocess Bags and Parts

Cryopreservation Media
MR1014 1 bottle
EUR 196.65
Description: Cryopreservation Media (100mL)

Cryopreservation Medium
TM024 100ml
EUR 175

Human Fibroblast-Like Synoviocyte Normal Tissue, Adult
ABC-TC3619 1 vial Ask for price
Description: Human Fibroblast-Like Synoviocytes (HFLS) are isolated from normal synovial tissues. They are cryopreserved at second passage and can be cultured and propagated at least 5 population doublings.

Human Fibroblast-Like Synoviocyte Osteo Arthritis, Adult
ABC-TC3620 1 vial Ask for price
Description: Human Fibroblast-Like Synoviocytes (HFLS) are isolated from synovial tissues obtained from patients with Rheumatoid Arthritis (RA) / Osteoarthritis (OA). They are cryopreserved at second passage and can be cultured and propagated at least 5 population doubling.

Serum Free Cryopreservation Medium
TM026 25 ml
EUR 50

Cryopreservation Media Kit (BRFF GTC-80)
MBS653029-1Kit 1Kit
EUR 435

Cryopreservation Media Kit (BRFF GTC-80)
MBS653029-5x1Kit 5x1Kit
EUR 1735

Waymouth Cryopreservation Medium
0459 100 ml
EUR 21.8

AddexBio Cryopreservation Medium
C0002-01-20mL RT vial
EUR 25

AddexBio Cryopreservation Medium
C0002-20mL RT vial
EUR 124.8

L7 hPSC Cryopreservation Solution, 50ml
LOFP-5002 each Ask for price

Cryopreservation Medium For General Use
CYRO-10001 20/50mL Ask for price

NCR Cryopreservation Medium For General Use
NCRC-10001 20/50mL Ask for price

Synoviocyte Growth Medium, Ready-to-Use, 500 ml, 10% Human Serum Supplement
M2700-10HS 500 ml bottle
EUR 120

Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult
ABC-TC3621 1 vial Ask for price
Description: Human Fibroblast-Like Synoviocytes (HFLS) are isolated from synovial tissues obtained from patients with Rheumatoid Arthritis (RA) / Osteoarthritis (OA). They are cryopreserved at second passage and can be cultured and propagated at least 5 population doubling.

Cryopreservation Medium For Neural Stem Cells
GUXNX-07031 20/50mL Ask for price

Serum-free cell cryopreservation solution
EGQA0073 100ml
EUR 80

Synoviocyte Growth Medium, Ready-to-Use, 500 ml, 2% Human Serum Supplement Factors
M2700-2HS 500 ml bottle
EUR 120

FreezeMe Two, Cryopreservation Medium Serum-free - 50 ml
CAFM2-F each
EUR 168.68

NCR Protein-Free Cryopreservation Medium For General Use
NCPF-10001 20/50mL Ask for price

Chemical Defined Xeno-free Cell Cryopreservation Medium
abx298009-20ml 20 ml
EUR 292.8

FreezeMe One, Cryopreservation Medium with Fetal Bovine Serum - 50 ml
CAFM1-F each
EUR 168.68

QuickFreezing-I Insect cell cryopreservation solution
E28X0310043-100 100ml
EUR 361.9

NCR Protein-Free Cryopreservation Medium For Neural Stem Cells
GUXNX-07021 20/50mL Ask for price

QuickFreezing-M Mammalian cell cryopreservation solution
E28X0310041-100 100ml
EUR 184.13

QuickFreezing-M Mammalian cell cryopreservation solution
E28X0310041-30 30ml
EUR 69.84

QuickFreezing-2×M Mammalian cell cryopreservation solution
E28X0310042-100 100ml
EUR 361.9

QuickFreezing-2×M Mammalian cell cryopreservation solution
E28X0310042-30 30ml
EUR 133.33

COOLCELL SV2 STEMCELL CRYOPRESERVATION SYSTEM INCLUDES THE XT STARTER BENCHTOP COOLER, COOLRACK SV2 AND COOLCELL SV2 CELL FREEZING CONTAINER FOR 12 INJECTABLE VIALS
432012 1/pk
EUR 1024.8
Description: BioCision; BioCision CoolCell

COOLCELL SV10 STEMCELL CRYOPRESERVATION SYSTEM INCLUDES THE XT STARTER BENCHTOP COOLER, COOLRACK SV10 AND COOLCELL SV10 CELL FREEZING CONTAINER FOR 6 INJECTABLE VIALS
432013 1/pk
EUR 1024.8
Description: BioCision; BioCision CoolCell

Human Synovial Fluid, OA
CDD-H-5000-OA 0.5 ml
EUR 300

Human Synovial Tissue, OA, FFPE
CDD-H-3000-ST-OA 1 H-E stained slide, 2 unstained slides
EUR 200

Human Synovial Tissue, Fresh, OA
CDD-H-6300-OA-5G-FRESH 5g
EUR 800

Human Synovial Tissue, OA, RNALater
CDD-H-6300-OA-1G-R 1g
EUR 250

Human Synovial Tissue, OA, OCT frozen
CDD-H-3000-OCT-ST-OA Flash frozen tissue in OCT medium
EUR 250

Human Synovial Tissue, OA, Snap Frozen
CDD-H-6300-OA-1G-F 1g
EUR 250

Human Synovial Tissue Explant Culture, OA
CDD-H-2920-OA Multiwell plate format
EUR 675

Human synovial apoptosis inhibitor 1, synoviolin(SYVN1) ELISA Kit
NSL2294Hu 96 wells
EUR 468

Human synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2610987-10x96StripWells 10x96-Strip-Wells
EUR 3040

Human synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2610987-48StripWells 48-Strip-Wells
EUR 285

Human synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2610987-5x96StripWells 5x96-Strip-Wells
EUR 1670

Human synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2610987-96StripWells 96-Strip-Wells
EUR 405

Human synovial apoptosis inhibitor 1, synoviolin(SYVN1) ELISA Kit
EIA07735h each
EUR 430

Total RNA - Human Tumor Tissue: Synoviosarcoma
R1235257-10 10 ug
EUR 480

Total Protein - Human Tumor Tissue: Synoviosarcoma
P1235257 1 mg
EUR 542

Tissue, Total Protein, Human Tumor, Synoviosarcoma
MBS657611-1mg 1mg
EUR 820

Tissue, Total Protein, Human Tumor, Synoviosarcoma
MBS657611-5x1mg 5x1mg
EUR 3470

Tissue, Total RNA, Human Tumor, Synoviosarcoma, BioGenomics
MBS638758-001mg 0.01mg
EUR 655

Tissue, Total RNA, Human Tumor, Synoviosarcoma, BioGenomics
MBS638758-5x001mg 5x0.01mg
EUR 2735

Human E3 ubiquitin- protein ligase synoviolin, SYVN1 ELISA KIT
ELI-29339h 96tests
EUR 696

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
abx383609-96tests 96 tests
EUR 1093.2

Human E3 ubiquitin-protein ligase synoviolin(SYVN1) Elisa Kit
EK713836 96 Wells
EUR 0.4

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
EK6825 96Т
EUR 799

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
AE16187HU-48Tests 48 Tests
EUR 325
Description: Human (Homo sapiens)

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
AE16187HU-96Tests 96 Tests
EUR 610
Description: Human (Homo sapiens)

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
AE16187HU-48T 48T
EUR 325
Description: Human (Homo sapiens)

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
AE16187HU-96T 96T
EUR 610
Description: Human (Homo sapiens)

Human E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) ELISA Kit
MBS109598-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) ELISA Kit
MBS109598-48StripWells 48-Strip-Wells
EUR 550

Human E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) ELISA Kit
MBS109598-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) ELISA Kit
MBS109598-96StripWells 96-Strip-Wells
EUR 765

Human E3 ubiquitin-protein ligase synoviolin,SYVN1 ELISA KIT
E5217Hu-1096T 10*96T
EUR 4122

Human E3 ubiquitin-protein ligase synoviolin,SYVN1 ELISA KIT
E5217Hu-48wells 48 wells
EUR 300

Human E3 ubiquitin-protein ligase synoviolin,SYVN1 ELISA KIT
E5217Hu-596T 5*96T
EUR 2061

Human E3 ubiquitin-protein ligase synoviolin,SYVN1 ELISA KIT
E5217Hu-96wells 96 wells
EUR 458

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
KTE60446-48T 48T
EUR 339
Description: This Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
KTE60446-96T 96T
EUR 589
Description: This Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
KTE60446-96T5 96 T×5
EUR 2629
Description: This Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.

Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit
KTE60446-96T50 96 T×50
EUR 24569
Description: This Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA Kit employs a two-site sandwich ELISA to quantitate SYVN1.

Human E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) ELISA Kit
abx383609-1096tests 10 × 96 tests Ask for price

Human E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) ELISA Kit
abx383609-596tests 5 × 96 tests Ask for price

Human E3 ubiquitin-protein ligase synoviolin, SYVN1 ELISA Kit
MBS1606133-10x96StripWells 10x96-Strip-Wells
EUR 3460

Human E3 ubiquitin-protein ligase synoviolin, SYVN1 ELISA Kit
MBS1606133-48StripWells 48-Strip-Wells
EUR 285

Human E3 ubiquitin-protein ligase synoviolin, SYVN1 ELISA Kit
MBS1606133-5x96StripWells 5x96-Strip-Wells
EUR 1750

Human E3 ubiquitin-protein ligase synoviolin, SYVN1 ELISA Kit
MBS1606133-96StripWells 96-Strip-Wells
EUR 425

Human E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) ELISA Kit
MBS9714112-48Tests 48Tests
EUR 340

Human E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) ELISA Kit
MBS9714112-5x96Tests 5x96Tests
EUR 1820

Human E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) ELISA Kit
MBS9714112-96Tests 96Tests
EUR 500

SYVN1 (untagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2
SC101046 10 µg Ask for price

SYVN1 (untagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1
SC309770 10 µg Ask for price

SYVN1 (untagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1
SC324298 10 µg Ask for price

SYVN1 (GFP-tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2
RG220540 10 µg Ask for price

SYVN1 (GFP-tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1
RG207132 10 µg Ask for price

ELISA kit for Human E3 ubiquitin-protein ligase synoviolin (SYVN1)
KTE60446-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Human E3 ubiquitin-protein ligase synoviolin (SYVN1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Recombinant Human E3 ubiquitin-protein ligase synoviolin (SYVN1)
MBS7030779-002mg 0.02mg
EUR 1965

Recombinant Human E3 ubiquitin-protein ligase synoviolin (SYVN1)
MBS7030779-01mg 0.1mg
EUR 2895

Recombinant Human E3 ubiquitin-protein ligase synoviolin (SYVN1)
MBS7030779-5x01mg 5x0.1mg
EUR 12975

Human E3 ubiquitin-Protein Ligase synoviolin, SYVN1 GENLISA ELISA
KBH5217 1 x 96 wells
EUR 286

SYVN1 (Myc-DDK-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1
RC207132 10 µg Ask for price

SYVN1 (Myc-DDK-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2
RC220540 10 µg Ask for price

Lenti ORF clone of Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, mGFP tagged
RC220540L2 10 µg Ask for price

Lenti ORF clone of Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, mGFP tagged
RC220540L4 10 µg Ask for price

Lenti-ORF clone of SYVN1 (mGFP-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1
RC207132L4 10 µg Ask for price

Lenti ORF clone of Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, Myc-DDK-tagged
RC220540L1 10 µg Ask for price

Lenti ORF clone of Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, Myc-DDK-tagged
RC220540L3 10 µg Ask for price

Recombinant Human E3 ubiquitin-protein ligase synoviolin (SYVN1), partial
MBS7092040-INQUIRE INQUIRE Ask for price

Lenti-ORF clone of SYVN1 (Myc-DDK-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1
RC207132L3 10 µg Ask for price

Lenti ORF particles, SYVN1 (mGFP-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1, 200ul, >10^7 TU/mL
RC207132L4V 200 µl Ask for price

Lenti ORF particles, SYVN1 (mGFP-tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, 200ul, >10^7 TU/mL
RC220540L2V 200 µl Ask for price

Lenti ORF particles, SYVN1 (mGFP-tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, 200ul, >10^7 TU/mL
RC220540L4V 200 µl Ask for price

Lenti ORF particles, SYVN1 (Myc-DDK tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, 200ul, >10^7 TU/mL
RC220540L1V 200 µl Ask for price

Lenti ORF particles, SYVN1 (Myc-DDK tagged) - Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2, 200ul, >10^7 TU/mL
RC220540L3V 200 µl Ask for price

Human Synovial Tissue Explant Culture, OA with wet weight determination provided for each explant in Excel spreadsheet
CDD-H-2920-OA-WW Multiwell plate format
EUR 875

Lenti ORF particles, SYVN1 (Myc-DDK-tagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 1, 200ul, >10^7 TU/mL
RC207132L3V 200 µl Ask for price

Rabbit anti-human synovial apoptosis inhibitor 1, synoviolin polyclonal Antibody
MBS716441-01mL 0.1mL
EUR 485

Rabbit anti-human synovial apoptosis inhibitor 1, synoviolin polyclonal Antibody
MBS716441-5x01mL 5x0.1mL
EUR 2175

Synovial Apoptosis Inhibitor 1, Synoviolin Antibody
20-abx115960
  • Ask for price
  • Ask for price
  • 150 ul
  • 50 ul

Synovial Apoptosis Inhibitor 1, Synoviolin Antibody
abx115960-100g 100 µg Ask for price

Synovial Apoptosis Inhibitor 1, Synoviolin Antibody
abx115960-10g 10 µg
EUR 612.5

Synovial Apoptosis Inhibitor 1, Synoviolin Antibody
abx115960-200g 200 µg Ask for price

Rat synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613006-10x96StripWells 10x96-Strip-Wells
EUR 3290

Rat synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613006-48StripWells 48-Strip-Wells
EUR 295

Rat synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613006-5x96StripWells 5x96-Strip-Wells
EUR 1800

Rat synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613006-96StripWells 96-Strip-Wells
EUR 450

Goat synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2615110-10x96StripWells 10x96-Strip-Wells
EUR 3545

Goat synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2615110-48StripWells 48-Strip-Wells
EUR 310

Goat synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2615110-5x96StripWells 5x96-Strip-Wells
EUR 1940

Goat synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2615110-96StripWells 96-Strip-Wells
EUR 475

Mouse synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613004-10x96StripWells 10x96-Strip-Wells
EUR 3290

Mouse synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613004-48StripWells 48-Strip-Wells
EUR 295

Mouse synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613004-5x96StripWells 5x96-Strip-Wells
EUR 1800

Mouse synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613004-96StripWells 96-Strip-Wells
EUR 450

Bovine synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613000-10x96StripWells 10x96-Strip-Wells
EUR 3545

Bovine synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613000-48StripWells 48-Strip-Wells
EUR 310

Bovine synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613000-5x96StripWells 5x96-Strip-Wells
EUR 1940

Bovine synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613000-96StripWells 96-Strip-Wells
EUR 475

Canine synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613001-10x96StripWells 10x96-Strip-Wells
EUR 3545

Canine synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613001-48StripWells 48-Strip-Wells
EUR 310

Canine synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613001-5x96StripWells 5x96-Strip-Wells
EUR 1940

Canine synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613001-96StripWells 96-Strip-Wells
EUR 475

Rabbit synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613007-10x96StripWells 10x96-Strip-Wells
EUR 3545

Rabbit synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613007-48StripWells 48-Strip-Wells
EUR 310

Rabbit synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613007-5x96StripWells 5x96-Strip-Wells
EUR 1940

Rabbit synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613007-96StripWells 96-Strip-Wells
EUR 475

Chicken synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613002-10x96StripWells 10x96-Strip-Wells
EUR 3545

Chicken synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit
MBS2613002-48StripWells 48-Strip-Wells
EUR 310

Furthermore, RA patients with low baseline serum miR-15a / 16 levels now the poor response of the 3-month disease-modifying antirheumatic drugs (DMARDs) therapy. Collectively, these studies revealed that miR-15a / 16 / SOX5 axis serves as the main driver of RA-FLSs invasion, migration and inflammatory responses in each negative feedback and correlated with treatment response to DMARDs in RA.

Shelby

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